Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis (Q34502637)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16541109%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis (English)

1 reference

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18 January 2020

2

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18 January 2020

Ian Eggleston

5

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18 January 2020

Daan van Aalten

6

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18 January 2020

author name string

Francesco V Rao

1

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18 January 2020

Fabrizio Villa

3

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18 January 2020

Matthew Allwood

4

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18 January 2020

language of work or name

English

0 references

publication date

16 March 2006

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18 January 2020

1 reference

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18 January 2020

volume

25

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18 January 2020

issue

7

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18 January 2020

page(s)

1569-1578

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Cloning, recombinant production, crystallization and preliminary X-ray diffraction studies of a family 84 glycoside hydrolase from Clostridium perfringens.

18 January 2020

cites work

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7 July 2018

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Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry

7 July 2018

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Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis

7 July 2018

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O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes

7 July 2018

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7 July 2018

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Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities

7 July 2018

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Refinement of macromolecular structures by the maximum-likelihood method

7 July 2018

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The CCP4 suite: programs for protein crystallography

7 July 2018

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

7 July 2018

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O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress

7 July 2018

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Carbohydrate-binding modules: fine-tuning polysaccharide recognition

7 July 2018

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Interactions of a family 18 chitinase with the designed inhibitor HM508 and its degradation product, chitobiono-delta-lactone

7 July 2018

1 reference

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Structural basis for ligand binding and processivity in cellobiohydrolase Cel6A from Humicola insolens

7 July 2018

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Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

7 July 2018

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Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state

7 July 2018

1 reference

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Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440316

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440316

Expression and characterization of active site mutants of hevamine, a chitinase from the rubber tree Hevea brasiliensis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440316

Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase

7 July 2018

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Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor

7 July 2018

1 reference

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Structural insights into the catalytic mechanism of a family 18 exo-chitinase

7 July 2018

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The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase

7 July 2018

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Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

7 July 2018

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Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

7 July 2018

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Crystal structure of hyaluronidase, a major allergen of bee venom

7 July 2018

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Functional expression of O-linked GlcNAc transferase. Domain structure and substrate specificity

7 July 2018

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Automated protein model building combined with iterative structure refinement

7 July 2018

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Automated MAD and MIR structure solution

7 July 2018

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Novel immunogenic antigen homologous to hyaluronidase in meningioma

7 July 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 July 2018

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Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

7 July 2018

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Protein structure comparison by alignment of distance matrices

7 July 2018

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Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.

7 July 2018

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Crystal structures of hevamine, a plant defence protein with chitinase and lysozyme activity, and its complex with an inhibitor

7 July 2018

1 reference

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c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas

7 July 2018

1 reference

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Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440316

Synthesis of the glycopeptide O-beta-D-galactopyranosyl-(1 to 3)-O-(2-acetamido-2-desoxy-alpha-D-galactopyranosyl)-(1 to 3)-L-serine and -L-threonine

7 July 2018

1 reference

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N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase

7 July 2018

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Improved methods for building protein models in electron density maps and the location of errors in these models

7 July 2018

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O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis

7 July 2018

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Mutational analysis of the catalytic domain of O-linked N-acetylglucosaminyl transferase

27 October 2018

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O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

27 October 2018

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Synthesis of an S-linked glycopeptide analog derived from human Tamm-Horsfall glycoprotein

27 October 2018

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Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.

27 October 2018

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Prediction of structure and functional residues for O-GlcNAcase, a divergent homologue of acetyltransferases

27 October 2018

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Facile synthesis of N-Fmoc-serine-S-GlcNAc: a potential molecular probe for the functional study of O-GlcNAc

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16541109

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16541109

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Substrate-Assisted Catalysis Unifies Two Families of Chitinolytic Enzymes

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601026

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7601026

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16541109%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16541109%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference