Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig (Q48133104)

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scientific article published in October 2003

Language	Label	Description	Also known as
English	Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig	scientific article published in October 2003

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scholarly article

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Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/14649883

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig (English)

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Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/14649883

Henry Seth Friedman

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object named as

Henry S Friedman

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Darell D. Bigner

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Darell D Bigner

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Allan H Friedman

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David A Reardon

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David A Reardon

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Roger E McLendon

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object named as

Roger E McLendon

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http://europepmc.org/abstract/MED/14649883

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Jeremy Rich

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Jennifer J Quinn

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Jennifer Quinn

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http://europepmc.org/abstract/MED/14649883

James H. Herndon

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James E Herndon

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http://europepmc.org/abstract/MED/14649883

Mitchel S. Berger

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Mitchel S Berger

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James M Provenzale

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object named as

James Provenzale

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Sandra Tourt-Uhlig

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object named as

Sandra Tourt-Uhlig

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13

object named as

Kara Penne

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http://europepmc.org/abstract/MED/14649883

Michael R Zalutsky

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object named as

Michael R Zalutsky

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2

object named as

Gamal Akabani

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object named as

Alison Paolino

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http://europepmc.org/abstract/MED/14649883

Carol J Wikstrand

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object named as

Carol Wikstrand

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object named as

Sandeep Kunwar

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http://europepmc.org/abstract/MED/14649883

Timothy T Stenzel

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object named as

Timothy Stenzel

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object named as

Ira Pastan

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author name string

John H Sampson

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http://europepmc.org/abstract/MED/14649883

Gary E Archer

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Steve Marcus

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Terence Wong

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http://europepmc.org/abstract/MED/14649883

Roger Williams

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http://europepmc.org/abstract/MED/14649883

Fan Yuan

23

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http://europepmc.org/abstract/MED/14649883

publication date

1 October 2003

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http://europepmc.org/abstract/MED/14649883

Journal of Neuro-Oncology

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http://europepmc.org/abstract/MED/14649883

65

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1

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27-35

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https://scigraph.springernature.com/pub.10.1023/a:1026290315809

0 references

Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

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Phase I trial of the diphtheria toxin/interleukin-2 fusion protein DAB486IL-2: efficacy in mycosis fungoides and other non-Hodgkin's lymphomas

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Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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High-flow microinfusion: tissue penetration and pharmacodynamics.

1 reference

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Comparison of various methods for delivering radiolabeled monoclonal antibody to normal rat brain.

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Targeted therapy of cancer with recombinant immunotoxins

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Convection-enhanced delivery of macromolecules in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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Chemotherapy for high-grade gliomas

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https://pubmed.ncbi.nlm.nih.gov/14649883

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Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results

1 reference

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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

1 reference

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Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.

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Therapeutic effects of genetically engineered toxin (DAB486IL-2) in patient with chronic lymphocytic leukaemia

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Annual report to the nation on the status of cancer (1973 through 1998), featuring cancers with recent increasing trends

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https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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Epidermal growth factor receptor expression in human gliomas

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12 December 2020

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Immunotoxins and central nervous system neoplasia

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Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors.

1 reference

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12 December 2020

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Heterogeneity in interleukin-13 receptor expression and subunit structure in squamous cell carcinoma of head and neck: differential sensitivity to chimeric fusion proteins comprised of interleukin-13 and a mutated form of Pseudomonas exotoxin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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Pharmacokinetics and tumor localization of 131I-labeled anti-tenascin monoclonal antibody 81C6 in patients with gliomas and other intracranial malignancies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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Recombinant Toxins for Cancer Treatment

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Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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Monoclonal antibody and F(ab')2 fragment delivery to tumor in patients with glioma: comparison of intracarotid and intravenous administration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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Expression of epidermal growth factor receptors in human brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

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Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

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https://pubmed.ncbi.nlm.nih.gov/14649883

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Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

12 December 2020

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Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion

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https://pubmed.ncbi.nlm.nih.gov/14649883

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Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

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Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

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Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells.

1 reference

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Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications

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Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials

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Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with single-photon emission computerized tomography imaging.

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Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor

1 reference

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Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin

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Recombinant toxins as novel therapeutic agents

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Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies

1 reference

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Phase I trial of an interleukin-2 fusion toxin (DAB486IL-2) in hematologic malignancies: complete response in a patient with Hodgkin's disease refractory to chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

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Effects of treatment on long-term survivors with malignant astrocytomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14649883

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Identifiers

10.1023/A:1026290315809

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/14649883

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/14649883

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