Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity. (Q48143728)

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10 December 2019

title

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity (English)

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10 December 2019

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2

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10 December 2019

author name string

M Tolar

1

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10 December 2019

S Chan

3

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10 December 2019

M P Mattson

4

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10 December 2019

M A Marques

5

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10 December 2019

K A Crutcher

6

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10 December 2019

language of work or name

English

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publication date

1 August 1999

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10 December 2019

published in

Journal of Neuroscience

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10 December 2019

volume

19

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10 December 2019

issue

16

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10 December 2019

page(s)

7100-7110

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A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.

10 December 2019

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Localization of a Domain in Apolipoprotein E with both Cytostatic and Cytotoxic Activity

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The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments

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Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

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The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding

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Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease

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The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

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12 December 2020

Increase in intracellular calcium ion in smooth muscle cells induced by low-density lipoprotein

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12 December 2020

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein

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12 December 2020

Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel

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12 December 2020

Alpha 2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins.

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12 December 2020

Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase

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beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

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12 December 2020

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor

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12 December 2020

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity

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12 December 2020

Basic Fibroblast Growth Factor Selectively Increases AMPA‐Receptor Subunit GluR1 Protein Level and Differentially Modulates Ca2+ Responses to AMPA and NMDA in Hippocampal Neurons

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Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity

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Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

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Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.

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Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

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39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

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12 December 2020

Apolipoprotein E: structure-function relationships

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12 December 2020

Glutamate neurotoxicity in cortical cell culture is calcium dependent

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12 December 2020

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12 December 2020

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions

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12 December 2020

Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3

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12 December 2020

Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein

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12 December 2020

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

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12 December 2020

Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated

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12 December 2020

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12 December 2020

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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12 December 2020

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

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12 December 2020

The toxic effect of sodium L-glutamate on the inner layers of the retina.

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12 December 2020

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein

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12 December 2020

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

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12 December 2020

Cytosolic calcium concentrations and cell death in vitro.

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12 December 2020

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

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12 December 2020

Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

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12 December 2020

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

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12 December 2020

A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins

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12 December 2020

Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide

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12 December 2020

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

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12 December 2020

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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12 December 2020

10.1523/JNEUROSCI.19-16-07100.1999

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

PubMed publication ID

10436064

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