The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+. (Q48148951)

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English	The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+. (English)

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

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9 February 2018

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Merino M

1

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Europe PubMed Central

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9 February 2018

http://europepmc.org/abstract/MED/10428073

Cano J

3

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

Machado A

4

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9 February 2018

http://europepmc.org/abstract/MED/10428073

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1 August 1999

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

Journal of Neurochemistry

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9 February 2018

http://europepmc.org/abstract/MED/10428073

73

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

2

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

750-757

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

Excitatory amino acid binding sites in the basal ganglia of the rat: A quantitative autoradiographic study

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The distribution of excitatory amino acid receptors in the normal human midbrain and basal ganglia with implications for Parkinson's disease: a quantitative autoradiographic study using [3H]MK-801, [3H]glycine, [3H]CNQX and [3H]kainate

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Kynurenic acid inhibits the activation of kainic and N-methyl-D-aspartic acid-sensitive ionotropic receptors by a different mechanism

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Glutamate and Parkinson's disease

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Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate

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Intrinsic membrane properties of neostriatal neurons can account for their low level of spontaneous activity

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Inhibition by dizocilpine (MK-801) of striatal dopamine release induced by MPTP and MPP+: possible action at the dopamine transporter

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Oxidative stress, glutamate, and neurodegenerative disorders

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Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.

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Primate models of movement disorders of basal ganglia origin

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The N-methyl-D-aspartate antagonist MK-801 fails to protect dopaminergic neurons from 1-methyl-4-phenylpyridinium toxicity in vitro

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Kynurenate inhibition of cell excitation decreases stroke size and deficits

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Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

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Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels

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7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex

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The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys

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21 January 2018

Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice

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21 January 2018

The non-NMDA glutamate antagonist NBQX blocks the local hippocampal toxicity of kainic acid, but not the diffuse extrahippocampal damage

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21 January 2018

The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat

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21 January 2018

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

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Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro

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21 January 2018

Synergism of the AMPA-antagonist NBQX and the NMDA-antagonist CPP with L-Dopa in models of Parkinson's disease

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Calcium as sculptor and destroyer of neural circuitry

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Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid

1 reference

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21 January 2018

Excitatory amino acids and neuropsychiatric disorders

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Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase.

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In vivo protection of striatum from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1 reference

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2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.

1 reference

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A role for non-NMDA excitatory amino acid receptors in regulating the basal activity of rat globus pallidus neurons and their activation by the subthalamic nucleus

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Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

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MK-801 fails to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridinium in rats

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1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.

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Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

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MK-801 partially protects against the acute MPP+ depleting effect on dopamine levels in rat striatal slices

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Aetiology of Parkinson's disease

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Identifiers

10.1046/J.1471-4159.1999.0730750.X

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10428073

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