Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases. (Q48168745)

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English	Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases.	scientific article

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4 March 2020

Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases (English)

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4 March 2020

prion protein family

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Matteo Stravalaci

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Emiliano Biasini

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Laura Tapella

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Antonio Bastone

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1 September 2013

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Biochemical Journal

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454

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417-425

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4 March 2020

The genetics of prion diseases

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https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

1 reference

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21 January 2018

Experimental transmission of Creutzfeldt-Jakob disease and related diseases to rodents

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21 January 2018

Prion diseases: what is the neurotoxic molecule?

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21 January 2018

Molecular distinction between pathogenic and infectious properties of the prion protein

1 reference

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21 January 2018

Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice

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21 January 2018

Prion protein NMR structure and familial human spongiform encephalopathies

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21 January 2018

Familial mutations and the thermodynamic stability of the recombinant human prion protein.

1 reference

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21 January 2018

Influence of amino acid substitutions related to inherited human prion diseases on the thermodynamic stability of the cellular prion protein.

1 reference

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21 January 2018

Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases

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21 January 2018

Conformational diversity in prion protein variants influences intermolecular beta-sheet formation

1 reference

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21 January 2018

NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features

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21 January 2018

Structural rearrangements at physiological pH: nuclear magnetic resonance insights from the V210I human prion protein mutant

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21 January 2018

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

1 reference

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21 January 2018

Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations

1 reference

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21 January 2018

Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Immunopurification of pathological prion protein aggregates

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

1 reference

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21 January 2018

Reiterating the epitope specificity of prion-specific mAb 3F4.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep

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21 January 2018

All major prion types recognised by a multiplex immunofluorometric assay for disease screening and confirmation in sheep.

1 reference

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21 January 2018

Prion protein expression in different species: analysis with a panel of new mAbs

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Epitope scanning reveals gain and loss of strain specific antibody binding epitopes associated with the conversion of normal cellular prion to scrapie prion.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Antigenic characterization of an abnormal isoform of prion protein using a new diverse panel of monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Eight prion strains have PrP(Sc) molecules with different conformations

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Distinct stability states of disease-associated human prion protein identified by conformation-dependent immunoassay

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Insoluble wild-type and protease-resistant mutant prion protein in brains of patients with inherited prion disease

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Identification of the prion protein allotypes which accumulate in the brain of sporadic and familial Creutzfeldt-Jakob disease patients.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Striking PrPsc heterogeneity in inherited prion diseases with the D178N mutation

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Allelic origin of protease-sensitive and protease-resistant prion protein isoforms in Gerstmann-Sträussler-Scheinker disease with the P102L mutation

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Dynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Prion Fibrillization Is Mediated by a Native Structural Element That Comprises Helices H2 and H3

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Aptamers against prion proteins and prions.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Polymorphism at residue 129 modulates the conformational conversion of the D178N variant of human prion protein 90-231.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

The oligomerization properties of prion protein are restricted to the H2H3 domain

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130563

21 January 2018

Identifiers

10.1042/BJ20130563

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23808898%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23808898%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

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