Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions (Q35515962)

8 August 2017

Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions (English)

1 reference

8 August 2017

0 references

Abhay Kumar Thakur

1

1 reference

8 August 2017

Atul Kumar Srivastava

2

1 reference

8 August 2017

Volety Srinivas

3

1 reference

8 August 2017

Kandala Venkata Ramana Chary

4

1 reference

8 August 2017

Chintalagiri Mohan Rao

5

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8 August 2017

language of work or name

English

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publication date

7 September 2011

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Journal of Biological Chemistry

8 August 2017

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8 August 2017

286

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8 August 2017

44

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8 August 2017

38533-38545

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Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion

8 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Horse prion protein NMR structure and comparisons with related variants of the mouse prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Functional implications of multistage copper binding to the prion protein.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Prion protein-detergent micelle interactions studied by NMR in solution

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Early onset prion disease from octarepeat expansion correlates with copper binding properties

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Ligand binding promotes prion protein aggregation--role of the octapeptide repeats

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

UV-light exposed prion protein fails to form amyloid fibrils

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Diversity in prion protein oligomerization pathways results from domain expansion as revealed by hydrogen/deuterium exchange and disulfide linkage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Structural characterization of flexible proteins using small-angle X-ray scattering

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

The charge structure of helix 1 in the prion protein regulates conversion to pathogenic PrPSc

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Aggregation/fibrillogenesis of recombinant human prion protein and Gerstmann-Sträussler-Scheinker disease peptides in the presence of metal ions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Rare large scale subdomain motions in prion protein can initiate aggregation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Interfaces and the driving force of hydrophobic assembly

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

The Octapeptide Repeats in Mammalian Prion Protein Constitute a pH-dependent Folding and Aggregation Site

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Stability and Cu(II) binding of prion protein variants related to inherited human prion diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Nuclear magnetic resonance spectroscopy studies on copper proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Copper-dependent functions for the prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Crystal structure of the human prion protein reveals a mechanism for oligomerization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Location and properties of metal-binding sites on the human prion protein.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Electron paramagnetic resonance evidence for binding of Cu(2+) to the C-terminal domain of the murine prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Determination of domain structure of proteins from X-ray solution scattering

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

NMR solution structure of the human prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Evidence for the role of PrP(C) helix 1 in the hydrophilic seeding of prion aggregates

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Copper stimulates endocytosis of the prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

The cellular prion protein binds copper in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Enthalpy-entropy compensation phenomena in water solutions of proteins and small molecules: A ubiquitous properly of water

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Heat capacity and entropy changes in processes involving proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform

12 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

High affinity binding between copper and full-length prion protein identified by two different techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

The amyloidogenic region of the human prion protein contains a high affinity (Met)(2)(His)(2) Cu(I) binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Evaluation of copper2+ affinities for the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

XAFS study of the high-affinity copper-binding site of human PrP(91-231) and its low-resolution structure in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Copper binding sites in the C-terminal domain of mouse prion protein: A hybrid (QM/MM) molecular dynamics study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

A novel copper(II) coordination at His186 in full-length murine prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Copper (II) ions potently inhibit purified PrPres amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Copper chelation delays the onset of prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Interaction of copper(II) with the prion peptide fragment HuPrP(76-114) encompassing four histidyl residues within and outside the octarepeat domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Automated matching of high- and low-resolution structural models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Ionic strength and transition metals control PrPSc protease resistance and conversion-inducing activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Cu(II) induces small-size aggregates with amyloid characteristics in two alleles of recombinant ovine prion proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Toward molecular dissection of PrPC-PrPSc interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Putative aggregation initiation sites in prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Copper induces conformational changes in the N-terminal part of cell-surface PrPC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

The effect of metal imbalances on scrapie neurodegeneration.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

The cellular prion protein binds copper in vivo

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207452

PRIMUS: a Windows PC-based system for small-angle scattering data analysis

26 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.265645

Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus

21 January 2018

1 reference

12 December 2020

Heat does not come in different colours: entropy-enthalpy compensation, free energy windows, quantum confinement, pressure perturbation calorimetry, solvation and the multiple causes of heat capacity effects in biomolecular interactions

1 reference

12 December 2020

Effect of metal ions on de novo aggregation of full-length prion protein

1 reference

12 December 2020

Metal-dependent alpha-helix formation promoted by the glycine-rich octapeptide region of prion protein

1 reference

12 December 2020

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

1 reference

12 December 2020

Prion protein helix1 promotes aggregation but is not converted into beta-sheet

1 reference

12 December 2020

Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details

1 reference

12 December 2020

Copper(II) Interaction with Unstructured Prion Domain Outside the Octarepeat Region: Speciation, Stability, and Binding Details of Copper(II) Complexes with PrP106−126 Peptides

1 reference

12 December 2020

Effect of interdomain dynamics on the structure determination of modular proteins by small-angle scattering

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.265645

1 reference

8 August 2017

1 reference

8 August 2017

1 reference