Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial (Q48168829)

9 February 2018

http://europepmc.org/abstract/MED/28681506

title

Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial (English)

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9 February 2018

http://europepmc.org/abstract/MED/28681506

0 references

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1

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3 June 2020

author name string

D C Tsitoura

2

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3 June 2020

D Quint

3

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3 June 2020

W Powley

4

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3 June 2020

L A Lee

5

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3 June 2020

publication date

5 July 2017

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9 February 2018

http://europepmc.org/abstract/MED/28681506

published in

Clinical & Experimental Allergy

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3 June 2020

volume

47

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3 June 2020

issue

9

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3 June 2020

page(s)

1193-1203

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Molecular and cellular mechanisms of allergic disease

3 June 2020

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21 January 2018

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

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A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma

21 January 2018

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Targeting Toll-like receptors: emerging therapeutics?

21 January 2018

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Pollinex Quattro: an innovative four injections immunotherapy in allergic rhinitis

21 January 2018

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Biological effects and clinical efficacy of a topical Toll-like receptor 7 agonist in seasonal allergic rhinitis: a parallel group controlled phase IIa study

21 January 2018

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VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis

21 January 2018

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Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study

21 January 2018

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

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The therapeutic potential of Toll-like receptor 7 stimulation in asthma

21 January 2018

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TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.

21 January 2018

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Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

21 January 2018

1 reference

Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma

21 January 2018

1 reference

Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement

21 January 2018

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Understanding the symptoms of the common cold and influenza

21 January 2018

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The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691).

21 January 2018

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Haematological effects of interferon-beta-1a (Rebif) therapy in multiple sclerosis

21 January 2018

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The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial

21 January 2018

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Efficacy, safety, and optimal dose selection of beclomethasone dipropionate nasal aerosol for seasonal allergic rhinitis in adolescents and adults

21 January 2018

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Efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with seasonal allergic rhinitis

21 January 2018

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Mastocytosis: update on pharmacotherapy and future directions

21 January 2018

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Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3

21 January 2018

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Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist

21 January 2018

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Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/CEA.12974

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28681506%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

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