Therapeutic manipulation of immune tolerance in allergic disease (Q37567423)

21 August 2017

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title

Therapeutic manipulation of immune tolerance in allergic disease (English)

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21 August 2017

2

Cezmi A Akdis

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21 August 2017

1

Mübeccel Akdis

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21 August 2017

1 August 2009

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Nature Reviews Drug Discovery

21 August 2017

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21 August 2017

8

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21 August 2017

645-660

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21 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrd2653

21 August 2017

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cites work

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Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity.

21 January 2018

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Immunostimulatory DNA reverses established allergen-induced airway remodeling

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Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics

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31 March 2020

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Healthy immune response to allergens: T regulatory cells and more

31 March 2020

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Immunological mechanisms of allergen-specific immunotherapy

31 March 2020

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Long-term clinical efficacy of grass-pollen immunotherapy

31 March 2020

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Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study

31 March 2020

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Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study).

31 March 2020

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Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro

31 March 2020

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Role of interleukin 10 in specific immunotherapy

31 March 2020

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Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy.

31 March 2020

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Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease.

31 March 2020

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IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

31 March 2020

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Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen

31 March 2020

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Lifetime of plasma cells in the bone marrow.

31 March 2020

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IgE in allergy and asthma today

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Blood-borne human plasma cells in steady state are derived from mucosal immune responses

31 March 2020

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31 March 2020

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Human Th17 cell clones and natural immune responses

31 March 2020

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IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

31 March 2020

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Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

31 March 2020

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Cytokine flow cytometry: understanding cytokine biology at the single-cell level

31 March 2020

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Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia?

31 March 2020

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Regulatory T cells and immune tolerance

31 March 2020

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Role of regulatory T cells in human diseases.

31 March 2020

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T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases

31 March 2020

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Absence of T-regulatory cell expression and function in atopic dermatitis skin

31 March 2020

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Regulatory NK cells suppress antigen-specific T cell responses

31 March 2020

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CD8+ gammadelta T regulatory cells mediate kidney allograft prolongation after oral exposure to alloantigen

31 March 2020

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Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells

31 March 2020

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In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure

31 March 2020

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Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study

31 March 2020

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Suppression of allergic inflammation by allergen-DNA-modified dendritic cells depends on the induction of Foxp3+ Regulatory T cells

31 March 2020

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Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells

31 March 2020

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Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent.

31 March 2020

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Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors

31 March 2020

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CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction.

31 March 2020

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CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling

31 March 2020

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Attenuation of allergen-induced airway hyperresponsiveness is mediated by airway regulatory T cells

31 March 2020

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Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial

31 March 2020

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Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia

31 March 2020

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Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

31 March 2020

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Multi-faceted control of autoaggression: Foxp3+ regulatory T cells in murine models of organ-specific autoimmune disease

31 March 2020

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Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.

31 March 2020

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Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.

31 March 2020

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Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma

31 March 2020

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Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists.

31 March 2020

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Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma.

31 March 2020

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Mechanisms of allergen-specific immunotherapy

31 March 2020

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

31 March 2020

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Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides.

31 March 2020

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Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis

31 March 2020

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Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

31 March 2020

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Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients

31 March 2020

1 reference

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

31 March 2020

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Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma.

31 March 2020

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Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expression

31 March 2020

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Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa

31 March 2020

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Mechanism and regulation of class switch recombination

31 March 2020

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How do we avoid developing allergy: modifications of the TH2 response from a B-cell perspective

31 March 2020

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Clinical relevance of the venom-specific immunoglobulin G antibody level during immunotherapy

31 March 2020

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Predictive value of venom-specific IgE, IgG and IgG subclass antibodies in patients on immunotherapy with honey bee venom.

31 March 2020

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Allergen-specific immunotherapy with recombinant grass pollen allergens

31 March 2020

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Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity

31 March 2020

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Low-affinity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing

31 March 2020

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Mechanisms of immunotherapy: IgG revisited

31 March 2020

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Mechanisms of immunotherapy.

31 March 2020

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31 March 2020

IgG4 breaking the rules

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Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

31 March 2020

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Isolation of high-affinity human IgE and IgG antibodies recognising Bet v 1 and Humicola lanuginosa lipase from combinatorial phage libraries

31 March 2020

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Vaccination for birch pollen allergy: comparison of the affinities of specific immunoglobulins E, G1 and G4 measured by surface plasmon resonance

31 March 2020

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Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: Inhibition of IgE-facilitated allergen binding

31 March 2020

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Competence and competition: the challenge of becoming a long-lived plasma cell

31 March 2020

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Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells

31 March 2020

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Allergen-specific conventional immunotherapy decreases immunoglobulin E-mediated basophil histamine releasability

31 March 2020

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Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells

31 March 2020

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Inhibition of mast cells by interleukin-10 gene transfer contributes to protection against acute myocarditis in rats

31 March 2020

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The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients

31 March 2020

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Priming of eosinophil adhesion in patients with birch pollen allergy during pollen season: effect of immunotherapy

31 March 2020

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Immunotherapy abrogates the generation of eosinophil and neutrophil chemotactic activity during pollen season

31 March 2020

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IL-17A-producing neutrophil-regulatory Tn lymphocytes

31 March 2020

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Future of allergen-specific immunotherapy: better understanding of the mechanisms, novel treatments, and long-term cure

31 March 2020

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Novel vaccines and adjuvants for allergen-specific immunotherapy

31 March 2020

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Standardization of allergen-specific immunotherapy vaccines

31 March 2020

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Development of new IgE specificities to allergenic components in birch pollen extract during specific immunotherapy studied with immunoblotting and Pharmacia CAP System

31 March 2020

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New insights in sublingual immunotherapy

31 March 2020

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Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis

31 March 2020

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Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody

31 March 2020

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Bypassing IgE and targeting T cells for specific immunotherapy of allergy

31 March 2020

1 reference

Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy

31 March 2020

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Treatment of cat allergy with T-cell reactive peptides

31 March 2020

1 reference

Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom.

31 March 2020

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Effects of peptide therapy on ex vivo T-cell responses

31 March 2020

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Allergen-derived long peptide immunotherapy down-regulates specific IgE response and protects from anaphylaxis

31 March 2020

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Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions

31 March 2020

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Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial

31 March 2020

1 reference

Immunoregulation by targeting T cells in the treatment of allergy and asthma

31 March 2020

1 reference

Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

31 March 2020

1 reference

Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis

31 March 2020

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A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy.

31 March 2020

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Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes

31 March 2020

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Vaccination with genetically engineered allergens prevents progression of allergic disease.

31 March 2020

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Clinical effects of immunotherapy with genetically modified recombinant birch pollen Bet v 1 derivatives

31 March 2020

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The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT).

31 March 2020

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Micro-arrayed wheat seed and grass pollen allergens for component-resolved diagnosis.

31 March 2020

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A chimeric human-cat fusion protein blocks cat-induced allergy

31 March 2020

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Targeting the MHC II presentation pathway in allergy vaccine development

31 March 2020

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Toll-like receptors and immune regulation: implications for cancer therapy

31 March 2020

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The multiple facets of toll-like receptors in transplantation biology

31 March 2020

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Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents

31 March 2020

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31 March 2020

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Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis

31 March 2020

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Pollinex Quattro: a novel and well-tolerated, ultra short-course allergy vaccine

31 March 2020

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Monophosphoryl lipid A (MPL) promotes allergen-induced immune deviation in favour of Th1 responses.

31 March 2020

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Therapeutic potential of Toll-like receptor 9 activation

31 March 2020

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CpG oligodeoxynucleotides can reverse Th2-associated allergic airway responses and alter the B7.1/B7.2 expression in a murine model of asthma

31 March 2020

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Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma

31 March 2020

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Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells

31 March 2020

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Airway remodelling in children: when does it start?

31 March 2020

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Immunostimulatory DNA Inhibits Transforming Growth Factor-β Expression and Airway Remodeling

31 March 2020

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Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure

31 March 2020

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Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA.

31 March 2020

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Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis

31 March 2020

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Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response

31 March 2020

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Immunomodulators for allergic respiratory disorders

31 March 2020

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Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation

31 March 2020

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Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.

31 March 2020

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Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study.

31 March 2020

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Intravenous anti-IL-5 monoclonal antibody reduces eosinophils and tenascin deposition in allergen-challenged human atopic skin.

31 March 2020

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Efficacy of soluble IL-4 receptor for the treatment of adults with asthma

31 March 2020

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Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis.

31 March 2020

1 reference

Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation

31 March 2020

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T cell trafficking in allergic asthma: the ins and outs

31 March 2020

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Interleukin-25 and interleukin-13 production by alveolar macrophages in response to particles

31 March 2020

1 reference

IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis

31 March 2020

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The IL-33/ST2 pathway: therapeutic target and novel biomarker

31 March 2020

1 reference

Mode of function of biological anti-TNF agents in the treatment of inflammatory bowel diseases

31 March 2020

1 reference

The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial.

31 March 2020

1 reference

Evidence of a role of tumor necrosis factor alpha in refractory asthma

31 March 2020

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A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma

31 March 2020

1 reference

Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis

31 March 2020

1 reference

Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis.

31 March 2020

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Immune regulation by histamine

31 March 2020

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The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

31 March 2020

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Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

31 March 2020

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Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venom immunotherapy

31 March 2020

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Comparative analysis of nasal and oral mucosa dendritic cells

31 March 2020

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Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells

31 March 2020

1 reference

Immune mechanisms of allergen-specific sublingual immunotherapy

31 March 2020

1 reference

Evaluation of serum IgG4 antibodies specific to grass pollen allergen components in the follow up of allergic patients undergoing subcutaneous and sublingual immunotherapy

31 March 2020

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Effect of sublingual immunotherapy with grass monomeric allergoid on allergen-specific T-cell proliferation and interleukin 10 production

31 March 2020

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Sublingual immunotherapy in children modulates allergen-induced in vitro expression of cytokine mRNA in PBMC.

31 March 2020

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Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation

31 March 2020

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Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: A double-blind, placebo-controlled trial

31 March 2020

1 reference

Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, randomized, placebo-controlled study

31 March 2020

1 reference

The effect of Fel d 1-derived T-cell peptides on upper and lower airway outcome measurements in cat-allergic subjects.

31 March 2020

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Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults

31 March 2020

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Direct intralymphatic injection of peptide vaccines enhances immunogenicity.

31 March 2020

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Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial

31 March 2020

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Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation

31 March 2020

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12 December 2020

Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis.

1 reference

12 December 2020

Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

1 reference

12 December 2020

T cell epitope specificity in human allergic and nonallergic subjects to bee venom phospholipase A2

1 reference

12 December 2020

Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route

1 reference

12 December 2020

Subclass typing of IgG antibodies formed by grass pollen-allergic patients during immunotherapy

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12 December 2020

IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy

1 reference

12 December 2020

Component-resolved diagnosis to optimize allergen-specific immunotherapy in the Mediterranean area.

1 reference

12 December 2020

A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation

1 reference

12 December 2020

Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice.

1 reference

12 December 2020

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells

1 reference

12 December 2020

Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial

1 reference

12 December 2020

Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures

1 reference

12 December 2020

B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10.

1 reference

12 December 2020

Characterization of a nontoxic monophosphoryl lipid A.

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12 December 2020

Monotherapy rapamycin allows an increase of CD4 CD25 FoxP3 T cells in renal recipients.

1 reference

12 December 2020

Induction of tolerance by IL-10-treated dendritic cells

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12 December 2020

Identifiers

DOI

10.1038/NRD2653

1 reference

21 August 2017

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PubMed ID

19644474