Huntingtin is degraded to small fragments by calpain after ischemic injury. (Q48206898)

9 February 2018

title

Huntingtin is degraded to small fragments by calpain after ischemic injury. (English)

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9 February 2018

Yun J Kim

5

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Manho Kim

1

object named as

Manho Kim

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9 February 2018

Jae-Kyu Roh

2

object named as

Jae-Kyu Roh

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9 February 2018

Lami Kang

4

object named as

Lami Kang

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9 February 2018

author name string

Byung Woo Yoon

3

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9 February 2018

Neil Aronin

6

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9 February 2018

Marian DiFiglia

7

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9 February 2018

language of work or name

English

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publication date

1 September 2003

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9 February 2018

number of pages

7

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based on heuristic

inferred from page(s)

published in

Experimental Neurology

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9 February 2018

volume

183

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9 February 2018

issue

1

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9 February 2018

page(s)

109-115

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9 February 2018

CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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Mutant protein in Huntington disease is resistant to proteolysis in affected brain

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Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

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Transient global ischemia in rats yields striatal projection neuron and interneuron loss resembling that in Huntington's disease

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7 January 2021

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7 January 2021

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

7 January 2021

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

7 January 2021

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Pretreatment with Calpain Inhibitor CEP-4143 Inhibits Calpain I Activation and Cytoskeletal Degradation, Improves Neurological Function, and Enhances Axonal Survival After Traumatic Spinal Cord Injury

7 January 2021

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Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

7 January 2021

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7 January 2021

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

7 January 2021

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

7 January 2021

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Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

7 January 2021

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Mutant huntingtin enhances excitotoxic cell death.

7 January 2021

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Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat.

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-4886(03)00132-8

1 reference

9 February 2018

PubMed ID

12957494

1 reference

9 February 2018