Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. (Q48232865)

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27 December 2019

title

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia (English)

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27 December 2019

author name string

Emmanuel Planel

1

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27 December 2019

Charles E Nolan

3

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27 December 2019

James E Finley

4

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27 December 2019

Li Liu

5

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27 December 2019

Yi Wen

6

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Pavan Krishnamurthy

7

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Mathieu Herman

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27 December 2019

Lili Wang

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Joel B Schachter

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Robert B Nelson

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27 December 2019

Lit-Fui Lau

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Karen E Duff

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language of work or name

English

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publication date

1 March 2007

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27 December 2019

published in

Journal of Neuroscience

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27 December 2019

volume

27

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27 December 2019

page(s)

3090-3097

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27 December 2019

issue

12

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Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration.

27 December 2019

cites work

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Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

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Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

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Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

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Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro

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12 December 2020

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

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12 December 2020

Tangling with hypothermia

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12 December 2020

Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity

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12 December 2020

Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain

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12 December 2020

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

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Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease

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Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites.

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12 December 2020

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10.1523/JNEUROSCI.4854-06.2007

Identifiers

DOI

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