PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. (Q48273067)

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scientific article published in November 2012

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English	PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.	scientific article published in November 2012

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scholarly article

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19 February 2020

PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice (English)

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19 February 2020

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Markus P Kummer

5

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19 February 2020

author name string

Mitsugu Yamanaka

1

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19 February 2020

Taizo Ishikawa

2

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19 February 2020

Angelika Griep

3

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19 February 2020

Daisy Axt

4

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19 February 2020

Michael T Heneka

6

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1 November 2012

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19 February 2020

Journal of Neuroscience

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17321-17331

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19 February 2020

Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

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Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase

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Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

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12 December 2020

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Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease

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CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils

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12 December 2020

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Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

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12 December 2020

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A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.

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12 December 2020

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CD36 mediates the innate host response to beta-amyloid

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12 December 2020

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Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

1 reference

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12 December 2020

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The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene

1 reference

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12 December 2020

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Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

1 reference

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12 December 2020

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The microglial "activation" continuum: from innate to adaptive responses

1 reference

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12 December 2020

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Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner.

1 reference

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12 December 2020

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Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

1 reference

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12 December 2020

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Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

1 reference

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12 December 2020

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PPARs in the brain

1 reference

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12 December 2020

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

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12 December 2020

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

1 reference

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12 December 2020

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Hematoma resolution as a therapeutic target: the role of microglia/macrophages

1 reference

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12 December 2020

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PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models

1 reference

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12 December 2020

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alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Immune activation in brain aging and neurodegeneration: too much or too little?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

based on heuristic

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The role of microglia in amyloid clearance from the AD brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Neuroinflammatory processes in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides (i).

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

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Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

based on heuristic

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Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

based on heuristic

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Risk of Alzheimer's disease and duration of NSAID use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

based on heuristic

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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

based on heuristic

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PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

1 reference

https://pubmed.ncbi.nlm.nih.gov/23197723

12 December 2020

based on heuristic

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Identifiers

10.1523/JNEUROSCI.1569-12.2012

1 reference

Europe PubMed Central

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19 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23197723%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23197723%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

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