Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival. (Q48347764)

10 February 2018

title

Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival. (English)

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10 February 2018

2

Rebecca A Betensky

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10 February 2018

author name string

Masahiro Mizoguchi

1

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10 February 2018

Tracy T Batchelor

3

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Derek C Bernay

4

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David N Louis

5

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Catherine L Nutt

6

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publication date

1 December 2006

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10 February 2018

Journal of Neuropathology & Experimental Neurology

published in

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10 February 2018

volume

65

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issue

12

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page(s)

1181-1188

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10 February 2018

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

21 January 2018

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Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

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The molecular and genetic basis of neurological tumours

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Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas

21 January 2018

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Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.

21 January 2018

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PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells

21 January 2018

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Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

21 January 2018

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

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Untangling the ErbB signalling network

21 January 2018

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Regulation of Raf-Akt Cross-talk

21 January 2018

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ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.

21 January 2018

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Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells

21 January 2018

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In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation

21 January 2018

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AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling.

21 January 2018

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Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens

21 January 2018

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor

21 January 2018

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Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells

21 January 2018

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Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin

21 January 2018

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Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer

21 January 2018

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Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.

21 January 2018

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The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas

21 January 2018

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Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

21 January 2018

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Erlotinib in gliomas: should selection be based on EGFR and Akt analyses?

21 January 2018

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

21 January 2018

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Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma

21 January 2018

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10.1097/01.JNEN.0000248549.14962.B2

21 January 2018

Identifiers

DOI

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10 February 2018

PubMed ID

17146292

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10 February 2018