Serum insulin-like growth factor I regulates brain amyloid-beta levels. (Q48454367)

11 February 2018

title

Serum insulin-like growth factor I regulates brain amyloid-beta levels. (English)

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11 February 2018

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1

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11 February 2018

Derek LeRoith

series ordinal

4

object named as

LeRoith D

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11 February 2018

Trejo JL

2

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11 February 2018

Gomez-Isla T

series ordinal

3

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11 February 2018

Torres-Aleman I

series ordinal

5

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11 February 2018

language of work or name

English

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publication date

4 November 2002

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11 February 2018

published in

Nature Medicine

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11 February 2018

volume

8

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11 February 2018

issue

12

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11 February 2018

page(s)

1390-1397

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11 February 2018

https://scigraph.springernature.com/pub.10.1038/nm1202-793

exact match

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cites work

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Insulin-like growth factor I restores motor coordination in a rat model of cerebellar ataxia

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Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy.

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Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus.

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Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus.

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Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

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Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner.

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Brain-blood permeability: TNF-alpha promotes escape of protein tracer from CSF to blood

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Insulin-like growth factor-I stimulates dephosphorylation of ikappa B through the serine phosphatase calcineurin (protein phosphatase 2B)

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7 January 2021

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

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7 January 2021

Identifiers

DOI

10.1038/NM1202-793

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11 February 2018

PubMed ID

12415260

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11 February 2018