Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans (Q48466996)

11 February 2018

title

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans (English)

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Gusheng Wu

1

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Zi-Hua Lu

series ordinal

2

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Neil Kulkarni

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3

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Robert W Ledeen

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4

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publication date

20 June 2012

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Journal of Neuroscience Research

published in

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volume

90

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issue

10

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page(s)

1997-2008

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Lubricating cell signaling pathways with gangliosides

cites work

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Gangliosides prevent excitotoxicity through activation of TrkB receptor

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

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Calcium homeostasis, selective vulnerability and Parkinson's disease

21 January 2018

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A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice

21 January 2018

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Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

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Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

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Asymmetric membrane ganglioside sialidase activity specifies axonal fate.

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Glycolipid and ganglioside metabolism imbalances in Huntington's disease.

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Caught in the act: alpha-synuclein is the culprit in Parkinson's disease

21 January 2018

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Role of membrane gangliosides in the binding and action of bacterial toxins.

21 January 2018

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Administration of GM1 ganglioside restores the dopamine content in striatum after chronic treatment with MPTP.

21 January 2018

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GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation.

21 January 2018

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Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder

21 January 2018

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Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture

21 January 2018

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Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance

21 January 2018

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In search of a solution to the sphinx-like riddle of GM1.

21 January 2018

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A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder

21 January 2018

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Impaired ganglioside metabolism in Huntington's disease and neuroprotective role of GM1.

21 January 2018

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GM1 specifically interacts with alpha-synuclein and inhibits fibrillation

21 January 2018

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Fuc-GM1 ganglioside mimics the receptor function of GM1 for cholera toxin

21 January 2018

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Animal models of Parkinson's disease progression

21 January 2018

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Molecular cloning and characterization of a plasma membrane-associated sialidase specific for gangliosides

21 January 2018

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Molecular pathophysiology of Parkinson's disease

21 January 2018

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Ganglioside GM1 binds to the Trk protein and regulates receptor function

21 January 2018

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The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

21 January 2018

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Influence of endogenous GM1 ganglioside on TrkB activity, in cultured neurons.

21 January 2018

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Brain gangliosides in axon-myelin stability and axon regeneration.

21 January 2018

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Oral administration of semisynthetic sphingolipids promotes recovery of striatal dopamine concentrations in a murine model of parkinsonism

21 January 2018

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MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences.

21 January 2018

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Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

21 January 2018

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Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase

21 January 2018

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Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase.

21 January 2018

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Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

21 January 2018

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Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis.

21 January 2018

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Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a

21 January 2018

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Antagonistic effect of ganglioside GM1 and GM3 on the activity and conformation of sarcoplasmic reticulum Ca(2+)-ATPase

21 January 2018

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Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies

21 January 2018

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Interaction of the delta-opioid receptor with GM1 ganglioside: conversion from inhibitory to excitatory mode

21 January 2018

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Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20.

21 January 2018

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Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.

21 January 2018

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Induction of calcium influx through TRPC5 channels by cross-linking of GM1 ganglioside associated with alpha5beta1 integrin initiates neurite outgrowth.

21 January 2018

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Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum

21 January 2018

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Ganglioside GM1 deficiency in effector T cells from NOD mice induces resistance to regulatory T-cell suppression

21 January 2018

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Mice lacking major brain gangliosides develop parkinsonism

21 January 2018

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Potentiation of a sodium-calcium exchanger in the nuclear envelope by nuclear GM1 ganglioside

21 January 2018

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Rat model of Parkinson's disease: chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+).

21 January 2018

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Letter to the Glyco-Forum: Cholera toxin B subunit binding does not correlate with GM1 expression: a study using mouse embryonic neural precursor cells

21 January 2018

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Identifiers

DOI

10.1002/JNR.23090

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11 February 2018

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11 February 2018