The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease (Q37054679)

18 August 2017

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title

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease (English)

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18 August 2017

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4

Joseph Jankovic

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18 August 2017

Tianhong Pan

1

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18 August 2017

Seiji Kondo

series ordinal

2

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18 August 2017

Weidong Le

series ordinal

3

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18 August 2017

language of work or name

English

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publication date

10 January 2008

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18 August 2017

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18 August 2017

131

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18 August 2017

Pt 8

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18 August 2017

1969-1978

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Expanding insights of mitochondrial dysfunction in Parkinson's disease.

18 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy: dual roles in life and death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Neuronal macroautophagy: from development to degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Inhibition of macroautophagy triggers apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

The autophagosomal-lysosomal compartment in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Oxidative stress and lysosomes: CNS-related consequences and implications for lysosomal enhancement strategies and induction of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy and intracellular surveillance: Modulating MHC class II antigen presentation with stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy and aging: the importance of maintaining "clean" cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Linking selective vulnerability to cell death mechanisms in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Gene dosage and pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Dysfunction of endocytic and autophagic pathways in a lysosomal storage disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Relationship between autophagy and apoptotic cell death in human neuroblastoma cells treated with paraquat: could autophagy be a "brake" in paraquat-induced apoptotic death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Intracellular protein degradation and its therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Oxidative stress and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy, mitochondria and cell death in lysosomal storage diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy as a regulated pathway of cellular degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

UCHL1 is a Parkinson's disease susceptibility gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Protein degradation and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Consequences of the selective blockage of chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Protective roles for induction of autophagy in multiple proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Ubiquitin-proteasome system and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Rapamycin pre-treatment protects against apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Involvement of macroautophagy in the dissolution of neuronal inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy and its possible roles in nervous system diseases, damage and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Potential therapeutic applications of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Huntingtin localization in brains of normal and Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Growing roles for the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Lithium induces autophagy by inhibiting inositol monophosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Autophagy in neuronal cell loss: a road to death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Oxidative stress and Alzheimer disease: the autophagy connection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

Heterozygousparkinpoint mutations are as common in control subjects as in Parkinson's patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM318

The role of autophagy during the early neonatal starvation period

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE03029

Identifiers

DOI

10.1093/BRAIN/AWM318

1 reference

18 August 2017

1 reference