Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. (Q48550878)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

Amanda N Sacino

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Mieu Brooks

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Alex B McKinney

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Michael A Thomas

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Gerry Shaw

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Todd E Golde

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Benoit I Giasson

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

language of work or name

English

0 references

publication date

1 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

volume

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

page(s)

12368-12378

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

issue

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

16 February 2020

cites work

1 reference

12 December 2020

The genetics of disorders with synuclein pathology and parkinsonism

1 reference

12 December 2020

A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease

1 reference

12 December 2020

Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders

1 reference

12 December 2020

Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy

1 reference

12 December 2020

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

1 reference

12 December 2020

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

1 reference

12 December 2020

Induction of peripherin expression in subsets of brain neurons after lesion injury or cerebral ischemia.

1 reference

12 December 2020

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.

1 reference

12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

12 December 2020

Are ubiquitination pathways central to Parkinson's disease?

1 reference

12 December 2020

A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114.

1 reference

12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

12 December 2020

Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

1 reference

12 December 2020

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

12 December 2020

alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease

1 reference

12 December 2020

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

1 reference

12 December 2020

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

1 reference

12 December 2020

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

1 reference

12 December 2020

The biochemistry of Parkinson's disease

1 reference

12 December 2020

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

1 reference

12 December 2020

Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells

1 reference

12 December 2020

Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

1 reference

12 December 2020

Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia

1 reference

12 December 2020

Synuclein activates microglia in a model of Parkinson's disease

1 reference

12 December 2020

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

1 reference

12 December 2020

Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

1 reference

12 December 2020

Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease

1 reference

12 December 2020

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

1 reference

12 December 2020

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

1 reference

12 December 2020

Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions

1 reference

12 December 2020

Immunological features of alpha-synuclein in Parkinson's disease

1 reference

12 December 2020

Research in motion: the enigma of Parkinson's disease pathology spread

1 reference

12 December 2020

Molecular mechanisms of alpha-synuclein neurodegeneration

1 reference

12 December 2020

Protein homeostasis and aging: taking care of proteins from the cradle to the grave

1 reference

12 December 2020

Identification of the amino acid sequence motif of alpha-synuclein responsible for macrophage activation.

1 reference

12 December 2020

Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization

1 reference

12 December 2020

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

1 reference

12 December 2020

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

1 reference

12 December 2020

A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation

1 reference

12 December 2020

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

1 reference

12 December 2020

The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease

1 reference

12 December 2020

Protein homeostasis in models of aging and age-related conformational disease

1 reference

12 December 2020

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

1 reference

12 December 2020

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.

1 reference

12 December 2020

Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.

1 reference

12 December 2020

α-Synuclein Alters Toll-Like Receptor Expression

1 reference

12 December 2020

E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment

1 reference

12 December 2020

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

1 reference

12 December 2020

Pathological roles of α-synuclein in neurological disorders

1 reference

12 December 2020

Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease

1 reference

12 December 2020

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

1 reference

12 December 2020

Prion-like spread of protein aggregates in neurodegeneration

1 reference

12 December 2020

Direct observation of the interconversion of normal and toxic forms of α-synuclein

1 reference

12 December 2020

α-Synuclein and protein degradation systems: a reciprocal relationship

1 reference

12 December 2020

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

1 reference

12 December 2020

Identification of proteins sensitive to thermal stress in human neuroblastoma and glioma cell lines

1 reference

12 December 2020

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

1 reference

12 December 2020

Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies

1 reference

12 December 2020

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

1 reference

12 December 2020

A novel α-synuclein missense mutation in Parkinson disease

1 reference

12 December 2020

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

1 reference

12 December 2020

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

1 reference

12 December 2020

Prion-like spreading of pathological α-synuclein in brain

1 reference

12 December 2020

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome

1 reference

12 December 2020

Thinking laterally about neurodegenerative proteinopathies

1 reference

12 December 2020

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

1 reference

12 December 2020

Conformational templating of α-synuclein aggregates in neuronal-glial cultures

1 reference

12 December 2020

Distinct α-synuclein strains differentially promote tau inclusions in neurons

1 reference

12 December 2020

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

1 reference

12 December 2020

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

1 reference

12 December 2020

Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies

1 reference

12 December 2020

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

1 reference

12 December 2020

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

12 December 2020

A vector for expressing foreign genes in the brains and hearts of transgenic mice

1 reference

12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

12 December 2020

1 reference

12 December 2020

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

1 reference

12 December 2020

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

12 December 2020

10.1523/JNEUROSCI.2102-14.2014

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

release_r2sgq3ovnvb6toa6nxitqtqgc4

16 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/r2sgq3ovnvb6toa6nxitqtqgc4

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25209277%20AND%20SRC:MED&resulttype=core&format=json