The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady. (Q48555497)

12 February 2018

title

The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady. (English)

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12 February 2018

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Frances M Ashcroft

1

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12 February 2018

publication date

24 July 2007

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12 February 2018

American Journal of Physiology - Endocrinology and Metabolism

published in

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12 February 2018

volume

293

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12 February 2018

issue

4

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12 February 2018

page(s)

E880-9

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12 February 2018

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion

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Intracellular ADP activates K+ channels that are inhibited by ATP in an insulin-secreting cell line

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Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide

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Focus on Kir6.2: a key component of the ATP-sensitive potassium channel

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D-Glucose inhibits potassium efflux from pancreatic islet cells

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Tolerance for ATP-insensitive K(ATP) channels in transgenic mice

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Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

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21 January 2018

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C-terminal tails of sulfonylurea receptors control ADP-induced activation and diazoxide modulation of ATP-sensitive K(+) channels

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21 January 2018

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21 January 2018

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Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

21 January 2018

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Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

21 January 2018

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A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome

21 January 2018

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Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

21 January 2018

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Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.

21 January 2018

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Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle

21 January 2018

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21 January 2018

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21 January 2018

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K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

21 January 2018

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Molecular etiologies of MODY and other early-onset forms of diabetes

21 January 2018

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Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

21 January 2018

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A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain.

21 January 2018

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Membrane phospholipid control of nucleotide sensitivity of KATP channels

21 January 2018

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A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

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Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions

21 January 2018

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Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels

21 January 2018

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Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.

21 January 2018

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A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells

21 January 2018

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Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy

21 January 2018

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Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells

21 January 2018

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Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

21 January 2018

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

21 January 2018

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A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels

21 January 2018

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Signaling in channel/enzyme multimers: ATPase transitions in SUR module gate ATP-sensitive K+ conductance

21 January 2018

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Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2.

21 January 2018

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Subunit stoichiometry of the pancreatic β-cell ATP-sensitive K+ channel

21 January 2018

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Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation i

21 January 2018

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Intracellular ATP directly blocks K+ channels in pancreatic B-cells

21 January 2018

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Glucose-induced decrease in Rb+ permeability in pancreatic β cells

21 January 2018

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10.1152/AJPENDO.00348.2007

21 January 2018

Identifiers

DOI

1 reference

12 February 2018

PubMed ID

17652156

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12 February 2018