Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase (Q48600823)

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scientific article published on 8 June 2014

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English	Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase	scientific article published on 8 June 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

corrigendum / erratum

Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.

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3

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

6

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

author name string

Silvia Sostegni

1

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

Alexei Diakov

2

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

Nigel Bunnett

4

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

Christoph Korbmacher

5

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

publication date

8 June 2014

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Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

Pfluegers Archiv

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Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

467

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

4

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

687-701

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

A segment of gamma ENaC mediates elastase activation of Na+ transport

1 reference

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Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.

1 reference

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21 January 2018

Selective role for TRPV4 ion channels in visceral sensory pathways.

1 reference

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21 January 2018

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

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21 January 2018

Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms

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21 January 2018

Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion

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Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.

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Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes

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Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2

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21 January 2018

Trypsin IV, a novel agonist of protease-activated receptors 2 and 4.

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

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Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4.

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21 January 2018

Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels

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21 January 2018

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21 January 2018

Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.

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Trypsin induces Ca(2+)-activated Cl- currents in X. laevis oocytes

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21 January 2018

The vanilloid transient receptor potential channel TRPV4: from structure to disease

1 reference

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21 January 2018

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

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21 January 2018

Phosphatidic acid and lysophosphatidic acid stimulate receptor-regulated membrane currents in the Xenopus laevis oocyte

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Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

1 reference

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21 January 2018

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.

1 reference

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21 January 2018

A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis

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21 January 2018

A novel neutrophil elastase inhibitor prevents elastase activation and surface cleavage of the epithelial sodium channel expressed in Xenopus laevis oocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A.

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia

1 reference

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21 January 2018

A calcium-activated and nucleotide-sensitive nonselective cation channel in M-1 mouse cortical collecting duct cells

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21 January 2018

Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1.

1 reference

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21 January 2018

Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

1 reference

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Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

1 reference

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21 January 2018

TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.

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21 January 2018

TRPV4 as osmosensor: a transgenic approach

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Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor

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21 January 2018

Forward genetic analysis reveals multiple gating mechanisms of TRPV4

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Electrophysiological properties of heteromeric TRPV4-C1 channels.

1 reference

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Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2.

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Interactions of mast cell tryptase with thrombin receptors and PAR-2.

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UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

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The puzzle of TRPV4 channelopathies

1 reference

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TRP channels: a TR(I)P through a world of multifunctional cation channels

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Molecular cloning of a potential proteinase activated receptor

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Proteinase-activated receptors, targets for kallikrein signaling

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Protease-activated receptors: contribution to physiology and disease

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Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

1 reference

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21 January 2018

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

1 reference

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Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception

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21 January 2018

Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)

1 reference

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Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways.

1 reference

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Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression

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Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs).

1 reference

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Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia

1 reference

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Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.

1 reference

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Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes

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Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).

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Optical recording reveals novel properties of GSK1016790A-induced vanilloid transient receptor potential channel TRPV4 activity in primary human endothelial cells

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Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

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N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Pa

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TRPV4: new therapeutic target for inflammatory bowel diseases

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Protease-activated receptors in inflammation, neuronal signaling and pain

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Identification and characterization of novel TRPV4 modulators

1 reference

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The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Modulation of TRPV4 gating by intra- and extracellular Ca2+.

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

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Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1539-6

21 January 2018

Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells

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The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

1 reference

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21 January 2018

TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis

1 reference

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Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis

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A transient calcium-dependent chloride current in the immature Xenopus oocyte

1 reference

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12 December 2020

based on heuristic

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Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24906497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRP channels in disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24906497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations

1 reference

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Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24906497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of neutrophil elastase in chronic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24906497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00424-014-1539-6

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/24906497

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