Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. (Q36635888)

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scientific article published on 3 January 2013

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English	Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.	scientific article published on 3 January 2013

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21 February 2020

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling (English)

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Nicholas Veldhuis

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Nigel W Bunnett

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Wolfgang B Liedtke

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Wolfgang Liedtke

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TinaMarie Lieu

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Silvia Amadesi

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Fe C Abogadie

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William Darby

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Journal of Biological Chemistry

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N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.

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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

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Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

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Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice

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Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8.

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Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins

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Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

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Protease-activated receptors: contribution to physiology and disease

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Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.

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Abnormal osmotic regulation in trpv4 -/- mice

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Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.

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ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

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Proteinase-activated receptors.

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Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms

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20 September 2018

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

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Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain.

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20 September 2018

Hypotonicity induces TRPV4-mediated nociception in rat.

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20 September 2018

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

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Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.

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A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity

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20 September 2018

The proteinase-activated receptor 2 is involved in nociception.

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An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

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21 January 2018

TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase

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12 December 2020

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TRP channels in disease

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12 December 2020

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Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells

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12 December 2020

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Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

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12 December 2020

based on heuristic

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Identifiers

10.1074/JBC.M112.438184

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21 February 2020

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21 February 2020

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21 February 2020

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