Acute effects of wortmannin on insulin's hemodynamic and metabolic actions in vivo. (Q48643533)

13 February 2018

title

Acute effects of wortmannin on insulin's hemodynamic and metabolic actions in vivo. (English)

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13 February 2018

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Eloise A Bradley

1

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13 February 2018

Michael G Clark

series ordinal

2

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13 February 2018

Stephen Rattigan

series ordinal

3

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13 February 2018

publication date

14 November 2006

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13 February 2018

American Journal of Physiology - Endocrinology and Metabolism

published in

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13 February 2018

volume

292

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13 February 2018

issue

3

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13 February 2018

page(s)

E779-87

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13 February 2018

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

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1 reference

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Wortmannin inhibits growth of human non-small-cell lung cancer in vitro and in vivo

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Autocrine regulation of glucose metabolism in pancreatic islets

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Blood flow and muscle metabolism: a focus on insulin action.

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Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo

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Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment

21 January 2018

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The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00407.2006

Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00407.2006

Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles

21 January 2018

1 reference

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

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Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

21 January 2018

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Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production.

21 January 2018

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Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment

21 January 2018

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Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.

21 January 2018

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Nitric oxide release accounts for insulin's vascular effects in humans

21 January 2018

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Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment

21 January 2018

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Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release

21 January 2018

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Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

21 January 2018

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Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo

21 January 2018

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Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment

21 January 2018

1 reference

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Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

21 January 2018

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Inhibitors of phosphatidylinositol 3-kinase amplify insulin release from islets of lean but not obese mice

21 January 2018

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Insulin sensitivity of muscle capillary recruitment in vivo

21 January 2018

1 reference

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10.1152/AJPENDO.00407.2006

21 January 2018

Identifiers

DOI

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13 February 2018

PubMed ID

17106063

1 reference

13 February 2018