Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. (Q48703300)

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scientific article published in June 1997

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English	Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.	scientific article published in June 1997

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3 November 2019

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals (English)

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3 November 2019

Alzheimer's disease

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apoptotic process

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object named as

M P Mattson

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Q Guo

1

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B L Sopher

2

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K Furukawa

3

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D G Pham

4

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N Robinson

5

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G M Martin

6

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publication date

1 June 1997

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Journal of Neuroscience

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4212-4222

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3 November 2019

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

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12 December 2020

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Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells

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12 December 2020

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Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

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12 December 2020

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Genetic and molecular advances in Alzheimer's disease

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12 December 2020

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Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture.

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12 December 2020

based on heuristic

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Immunohistochemical evidence for apoptosis in Alzheimer's disease.

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https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

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Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons

1 reference

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12 December 2020

based on heuristic

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

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Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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https://pubmed.ncbi.nlm.nih.gov/9151738

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Are reactive oxygen species involved in Alzheimer's disease?

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https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

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Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent

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https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Protein oxidation and aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemistry of altered brain proteins in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium ionophore increases amyloid beta peptide production by cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for apoptotic cell death in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane topology of the C. elegans SEL-12 presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Evidence for calcium regulation of spinal cord motoneuron death in the chick embryo in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

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Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radical AGEing in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum- and bradykinin-induced calcium transients in familial Alzheimer's fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein topology of presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the colchicine susceptibility of microtubules associated with neurite outgrowth: studies with nerve growth factor-responsive PC12 pheochromocytoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid polypeptide increases calcium-uptake in PC12 cells: a possible mechanism for its cellular toxicity in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9151738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.17-11-04212.1997

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3 November 2019

1 reference

Europe PubMed Central

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3 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9151738%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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