Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice. (Q48705239)

14 February 2018

title

Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice. (English)

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14 February 2018

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Shen KF

1

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14 February 2018

Crain SM

series ordinal

2

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14 February 2018

language of work or name

English

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publication date

1 May 1997

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14 February 2018

published in

Brain Research

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14 February 2018

volume

757

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14 February 2018

issue

2

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14 February 2018

page(s)

176-190

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14 February 2018

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

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Actions of etorphine hydrochloride, (M99): a potent morphine-like agent

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After chronic opioid exposure sensory neurons become supersensitive to the excitatory effects of opioid agonists and antagonists as occurs after acute elevation of GM1 ganglioside

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Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment

7 January 2021

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Chronic morphine-treated sensory ganglion neurons remain supersensitive to the excitatory effects of naloxone for months after return to normal culture medium: an in vitro model of 'protracted opioid dependence'.

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Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures

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Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells

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Chronic selective activation of excitatory opioid receptor functions in sensory neurons results in opioid 'dependence' without tolerance

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Antagonists at excitatory opioid receptors on sensory neurons in culture increase potency and specificity of opiate analgesics and attenuate development of tolerance/dependence

7 January 2021

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Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells.

7 January 2021

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7 January 2021

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Chronic opioid treatment of neuroblastoma x dorsal root ganglion neuron hybrid F11 cells results in elevated GM1 ganglioside and cyclic adenosine monophosphate levels and onset of naloxone-evoked decreases in membrane K+ currents

7 January 2021

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7 January 2021

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Postoperative pain relief with naloxone. Severe respiratory depression and pain after high dose buprenorphine

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-8993(97)00197-2

1 reference

14 February 2018

PubMed ID

9200746

1 reference

14 February 2018