Purkinje-cell degeneration in prion protein-deficient mice is associated with a cerebellum-specific Doppel protein species signature (Q48908089)

16 February 2018

title

Purkinje-cell degeneration in prion protein-deficient mice is associated with a cerebellum-specific Doppel protein species signature (English)

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author name string

Roméo Al Bersaoui

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Isabelle Robert

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Yves Lutz

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Ghislaine Sommermeyer-Leroux

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Hirotomo Shibaguchi

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Dominique Aunis

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Jean-Paul Fuchs

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language of work or name

English

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publication date

19 April 2005

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published in

FEBS Letters

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volume

579

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issue

12

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page(s)

2715-2721

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Novel proteinaceous infectious particles cause scrapie

cites work

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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

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129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

21 January 2018

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Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene.

21 January 2018

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Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

21 January 2018

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Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain

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Two different neurodegenerative diseases caused by proteins with similar structures

21 January 2018

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Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice

21 January 2018

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Absence of the prion protein homologue Doppel causes male sterility

21 January 2018

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Doppel-induced cerebellar degeneration in transgenic mice

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Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

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Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic due to Purkinje cell degeneration

21 January 2018

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Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment

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Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions

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An improved sodium dodecyl sulfate-polyacrylamide gel electrophoresis system for the analysis of membrane protein complexes

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Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl.

21 January 2018

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The human "prion-like" protein Doppel is expressed in both Sertoli cells and spermatozoa

21 January 2018

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Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region

21 January 2018

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Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function

21 January 2018

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A marked disparity between the expression of prion protein and its message by neurones of the CNS.

21 January 2018

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Prion protein (PrPc) immunocytochemistry and expression of the green fluorescent protein reporter gene under control of the bovine PrP gene promoter in the mouse brain

21 January 2018

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GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice.

21 January 2018

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Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease

21 January 2018

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Altered circadian activity rhythms and sleep in mice devoid of prion protein

21 January 2018

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10.1016/J.FEBSLET.2005.04.007

21 January 2018

Identifiers

DOI

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16 February 2018

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16 February 2018