Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. (Q48924423)

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11 February 2020

title

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair (English)

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11 February 2020

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Nils Zuiderveen Borgesius

1

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11 February 2020

Gijsbertus van der Horst

6

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11 February 2020

Ype Elgersma

10

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11 February 2020

author name string

Monique C de Waard

2

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11 February 2020

Ingrid van der Pluijm

3

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11 February 2020

Azar Omrani

4

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11 February 2020

Gerben C M Zondag

5

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11 February 2020

David W Melton

7

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11 February 2020

Jan H J Hoeijmakers

8

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11 February 2020

Dick Jaarsma

9

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language of work or name

English

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publication date

1 August 2011

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11 February 2020

published in

Journal of Neuroscience

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11 February 2020

volume

31

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11 February 2020

issue

35

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11 February 2020

page(s)

12543-12553

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Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

11 February 2020

cites work

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12 December 2020

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Insulin-like growth factors as mediators of functional plasticity in the adult brain

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Action of DNA repair endonuclease ERCC1/XPF in living cells

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ATF3 and stress responses.

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Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats

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Does oxidative damage to DNA increase with age?

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Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene.

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ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain

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Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

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Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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Free radical-induced damage to DNA: mechanisms and measurement

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ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth

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The neurobiology of memory changes in normal aging

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Divide and conquer: nucleotide excision repair battles cancer and ageing

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Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

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Long-term potentiation and the ageing brain

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Impact of aging on hippocampal function: plasticity, network dynamics, and cognition

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Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits.

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Interaction of age and chronic estradiol replacement on memory and markers of brain aging

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Time course and distribution of neuronal degeneration in the dentate gyrus of rat after adrenalectomy: A silver impregnation study

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Cockayne syndrome: Review of 140 cases

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The aging hippocampus: cognitive, biochemical and structural findings

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ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

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12 December 2020

DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy

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Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain.

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Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice

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Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in rats.

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Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus

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Translational regulatory mechanisms in persistent forms of synaptic plasticity

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Reactive oxygen species and synaptic plasticity in the aging hippocampus

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12 December 2020

Evidence of increased oxidative damage in subjects with mild cognitive impairment.

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12 December 2020

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease.

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12 December 2020

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

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12 December 2020

ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation

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12 December 2020

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

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The P53 pathway: what questions remain to be explored?

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12 December 2020

Correlation between glial fibrillary acidic protein-positive astrocytes and age in the human hippocampus.

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Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression

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12 December 2020

Impaired trace and contextual fear conditioning in aged rats.

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12 December 2020

DNA repair in neurons: so if they don't divide what's to repair?

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12 December 2020

DNA repair in differentiated cells: some new answers to old questions

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12 December 2020

Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice

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12 December 2020

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

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12 December 2020

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship

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12 December 2020

Candidate mechanisms for chemotherapy-induced cognitive changes

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12 December 2020

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome

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12 December 2020

Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

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12 December 2020

Interstrand crosslink repair: can XPF-ERCC1 be let off the hook?

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12 December 2020

Caspase activation cascades in apoptosis

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12 December 2020

A neurological phenotype in mice with DNA repair gene Ercc1 deficiency

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12 December 2020

The 8,5'-cyclopurine-2'-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair

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12 December 2020

ERCC1-XPF endonuclease facilitates DNA double-strand break repair

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12 December 2020

Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats

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12 December 2020

The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain.

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12 December 2020

ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress

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12 December 2020

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

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12 December 2020

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

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12 December 2020

Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice

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12 December 2020

Creating context for the use of DNA adduct data in cancer risk assessment: II. Overview of methods of identification and quantitation of DNA damage.

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12 December 2020

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

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DNA Damage, Aging, and Cancer

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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

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Aging and oxidatively damaged nuclear DNA in animal organs.

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12 December 2020

An active role for astrocytes in synaptic plasticity?

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12 December 2020

A critical role for IGF-II in memory consolidation and enhancement.

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12 December 2020

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

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12 December 2020

GFAP mRNA increases with age in rat and human brain

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12 December 2020

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

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12 December 2020

Mutational analysis of the human nucleotide excision repair gene ERCC1

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12 December 2020

Subregion- and cell type-restricted gene knockout in mouse brain

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12 December 2020

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

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12 December 2020

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

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12 December 2020

Age-dependent increase of indigenous DNA adducts in rat brain is associated with a lipid peroxidation product

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Insulin-like growth factor-1 ameliorates age-related behavioral deficits.

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12 December 2020

10.1523/JNEUROSCI.1589-11.2011

Identifiers

DOI

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11 February 2020

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11 February 2020

PubMed publication ID

21880916

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