Barrier-tissue macrophages: functional adaptation to environmental challenges (Q49048144)

18 February 2018

title

Barrier-tissue macrophages: functional adaptation to environmental challenges (English)

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18 February 2018

Calum C Bain

3

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Charlotte Scott

object named as

Charlotte L Scott

series ordinal

2

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Allan Mowat

series ordinal

1

object named as

Allan McI Mowat

1 reference

18 February 2018

language of work or name

English

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publication date

7 November 2017

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18 February 2018

published in

Nature Medicine

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18 February 2018

volume

23

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18 February 2018

issue

11

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18 February 2018

page(s)

1258-1270

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18 February 2018

The macrophage: past, present and future

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Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

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Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.

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The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis.

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Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

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Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

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Activation of pattern recognition receptors up-regulates metallothioneins, thereby increasing intracellular accumulation of zinc, autophagy, and bacterial clearance by macrophages

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Macrophages promote epithelial repair through hepatocyte growth factor secretion.

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Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity

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Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury

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The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration

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CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response.

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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

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IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis

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Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation

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An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation.

21 January 2018

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 January 2018

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Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

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Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function

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Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

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CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis.

21 January 2018

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Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation

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Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.

21 January 2018

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Regional specialization within the intestinal immune system

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Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes

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The identification and developmental requirements of colonic CD169⁺ macrophages

21 January 2018

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Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

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Neuro-Immune Interactions at Barrier Surfaces

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Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung

21 January 2018

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Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes

21 January 2018

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Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice

21 January 2018

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Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF.

21 January 2018

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Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

21 January 2018

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Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.

21 January 2018

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Antiinflammatory Roles of Peroxisome Proliferator–activated Receptor γ in Human Alveolar Macrophages

21 January 2018

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Alveolar macrophages: plasticity in a tissue-specific context

21 January 2018

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Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation

21 January 2018

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Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance

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Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

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Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.

21 January 2018

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Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes

21 January 2018

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Three Unique Interstitial Macrophages in the Murine Lung at Steady State

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High-dimensional analysis of the murine myeloid cell system.

21 January 2018

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Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice

21 January 2018

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Extensive local adaptation within the chemosensory system following Drosophila melanogaster's global expansion

21 January 2018

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Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

21 January 2018

1 reference

Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules

21 January 2018

1 reference

The origins and functions of dendritic cells and macrophages in the skin

21 January 2018

1 reference

Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells.

21 January 2018

1 reference

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

21 January 2018

1 reference

Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells.

21 January 2018

1 reference

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

21 January 2018

1 reference

GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells

21 January 2018

1 reference

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.

21 January 2018

1 reference

Langerhans cells are precommitted to immune tolerance induction

21 January 2018

1 reference

Acute ablation of Langerhans cells enhances skin immune responses

21 January 2018

1 reference

Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin

21 January 2018

1 reference

C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages

21 January 2018

1 reference

Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects

21 January 2018

1 reference

Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation

21 January 2018

1 reference

Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophages

21 January 2018

1 reference

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

21 January 2018

1 reference

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

21 January 2018

1 reference

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

21 January 2018

1 reference

CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens

21 January 2018

1 reference

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

21 January 2018

1 reference

Distribution of the CD68 macrophage/myeloid associated antigen

21 January 2018

1 reference

The macrophage scavenger receptor CD163.

21 January 2018

1 reference

The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota

21 January 2018

1 reference

Gut-liver axis and sensing microbes

21 January 2018

1 reference

Oral tolerance to food protein

21 January 2018

1 reference

Intestinal venous drainage through the liver is a prerequisite for oral tolerance induction

21 January 2018

1 reference

Tolerogenic role of Kupffer cells in allergic reactions

21 January 2018

1 reference

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells

21 January 2018

1 reference

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.

21 January 2018

1 reference

Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance.

21 January 2018

1 reference

Antigen-presenting cell function in the tolerogenic liver environment.

21 January 2018

1 reference

Liver macrophages in tissue homeostasis and disease

21 January 2018

1 reference

Macrophages and systemic iron homeostasis.

21 January 2018

1 reference

Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates

21 January 2018

1 reference

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 January 2018

1 reference

Hemochromatosis and Vibrio vulnificus wound infections.

21 January 2018

1 reference

Multiple hepatic abscesses due to Yersinia enterocolitica infection secondary to primary haemochromatosis.

21 January 2018

1 reference

Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis

21 January 2018

1 reference

The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis.

21 January 2018

1 reference

Macrophages in intestinal homeostasis and inflammation

21 January 2018

1 reference

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.

21 January 2018

1 reference

CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.

21 January 2018

1 reference

Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice

21 January 2018

1 reference

Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice

21 January 2018

1 reference

Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells.

21 January 2018

1 reference

Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytes.

21 January 2018

1 reference

Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection

21 January 2018

1 reference

Alternatively activated macrophages in helminth infections

21 January 2018

1 reference

Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation

21 January 2018

1 reference

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection

21 January 2018

1 reference

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

21 January 2018

1 reference

Suppression of experimental colitis by intestinal mononuclear phagocytes.

21 January 2018

1 reference

Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease

21 January 2018

1 reference

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

21 January 2018

1 reference

Host responses in tissue repair and fibrosis

21 January 2018

1 reference

Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis

21 January 2018

1 reference

Colonic epithelial response to injury requires Myd88 signaling in myeloid cells

21 January 2018

1 reference

Mechanisms of Organ Injury and Repair by Macrophages

21 January 2018

1 reference

Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages

21 January 2018

1 reference

Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

21 January 2018

1 reference

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

21 January 2018

1 reference

The alveolar macrophages in asthma: a double-edged sword

21 January 2018

1 reference

Alveolar macrophages modulate allergic inflammation in a murine model of asthma.

21 January 2018

1 reference

Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.

21 January 2018

1 reference

Effect of exposure to silica on human alveolar macrophages in supporting growth activity in type II epithelial cells

21 January 2018

1 reference

Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice

21 January 2018

1 reference

Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.

21 January 2018

1 reference

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

21 January 2018

1 reference

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation

21 January 2018

1 reference

A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18.

21 January 2018

1 reference

Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury

21 January 2018

1 reference

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

21 January 2018

1 reference

Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses

21 January 2018

1 reference

Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells

21 January 2018

1 reference

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

21 January 2018

1 reference

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

21 January 2018

1 reference

Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.

21 January 2018

1 reference

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection

21 January 2018

1 reference

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

21 January 2018

1 reference

Role of Kupffer cells in the pathogenesis of liver disease

21 January 2018

1 reference

Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10.

21 January 2018

1 reference

Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats

21 January 2018

1 reference

The role of Kupffer cells in hepatitis B and hepatitis C virus infections.

21 January 2018

1 reference

Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury

21 January 2018

1 reference

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury.

21 January 2018

1 reference

Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection

21 January 2018

1 reference

Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages

21 January 2018

1 reference

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function

21 January 2018

1 reference

Specification of tissue-resident macrophages during organogenesis.

21 January 2018

1 reference

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

21 January 2018

1 reference

Monocyte differentiation and antigen-presenting functions

21 January 2018

1 reference

Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis

21 January 2018

1 reference

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

21 January 2018

1 reference

Hepatic Suppression of Sensitization to Antigen absorbed into the Portal System

21 January 2018

1 reference

Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells

21 January 2018

1 reference

7 January 2021

Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD

1 reference

7 January 2021

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD

1 reference

7 January 2021

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.

1 reference

7 January 2021

Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1⁺ macrophages to CD103⁺ dendritic cells

1 reference

7 January 2021

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

1 reference

7 January 2021

Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages

1 reference

7 January 2021

IL-10-producing lung interstitial macrophages prevent neutrophilic asthma

1 reference

7 January 2021

Interstitial pulmonary macrophages produce platelet-derived growth factor that stimulates rat lung fibroblast proliferation in vitro

1 reference

7 January 2021

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

1 reference

7 January 2021

Multilineage communication regulates human liver bud development from pluripotency.

1 reference

7 January 2021

The effect of portacaval shunt on delayed-hypersensitivity responses following antigen feeding

1 reference

7 January 2021

Induction of immune hyporesponsiveness after portal vein immunization with ovalbumin

1 reference

7 January 2021

Role of Kupffer cells in the induction of tolerance after liver transplantation

1 reference

7 January 2021

Murine liver antigen presenting cells control suppressor activity of CD4+CD25+ regulatory T cells

1 reference

7 January 2021

Investigation of a researcher's death due to septicemic plague

1 reference

7 January 2021

Alveolar macrophage interleukin (IL)-10 and IL-12 production in atopic asthma

1 reference

7 January 2021

Increased expression of the CD80 accessory molecule by alveolar macrophages in asthmatic subjects and its functional involvement in allergen presentation to autologous TH2 lymphocytes

1 reference

7 January 2021

Enhanced production of an EGF-like growth factor by parenchymal macrophages following bleomycin-induced pulmonary injury

1 reference

7 January 2021

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

1 reference

7 January 2021

CD1a on Langerhans cells controls inflammatory skin disease.

1 reference

7 January 2021

GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice

1 reference

12 December 2020

Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

1 reference

12 December 2020

Kupffer cell blockade inhibits induction of tolerance by the portal venous route

1 reference

12 December 2020

Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease

1 reference

12 December 2020

Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing

1 reference

12 December 2020

CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver

1 reference

12 December 2020

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

1 reference

12 December 2020

Blockade of Kupffer cells by gadolinium chloride reduces lipid peroxidation and protects liver from ischemia/reperfusion injury

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.4430

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18 February 2018

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18 February 2018