Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth. (Q49627330)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376023%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth (English)

1 reference

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13 March 2020

1 reference

3

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13 March 2020

Lara Console

4

1 reference

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13 March 2020

author name string

Mariafrancesca Scalise

1

1 reference

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13 March 2020

Lorena Pochini

2

1 reference

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13 March 2020

Cesare Indiveri

5

1 reference

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13 March 2020

publication date

11 December 2017

1 reference

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13 March 2020

published in

Frontiers in Oncology

1 reference

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13 March 2020

volume

7

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13 March 2020

page(s)

306

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A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

13 March 2020

cites work

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The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.

22 May 2018

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Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma.

22 May 2018

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22 May 2018

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A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis

22 May 2018

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Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

22 May 2018

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SLC7A5 Functions as a Downstream Target Modulated by CRKL in Metastasis Process of Gastric Cancer SGC-7901 Cells

22 May 2018

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Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism

22 May 2018

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LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells

22 May 2018

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From Krebs to clinic: glutamine metabolism to cancer therapy.

22 May 2018

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LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma

22 May 2018

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Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell

22 May 2018

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Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.

22 May 2018

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LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs

22 May 2018

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Reductive carboxylation supports redox homeostasis during anchorage-independent growth

22 May 2018

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Glutamine transport. From energy supply to sensing and beyond

22 May 2018

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Large amino acid transporter 1 mediated glutamate modified docetaxel-loaded liposomes for glioma targeting

22 May 2018

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Glutamine transporters in mammalian cells and their functions in physiology and cancer

22 May 2018

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Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells

22 May 2018

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High expression of Solute Carrier Family 1, member 5 (SLC1A5) is associated with poor prognosis in clear-cell renal cell carcinoma

22 May 2018

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Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

22 May 2018

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ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer.

22 May 2018

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Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening

22 May 2018

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Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14.

22 May 2018

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LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter.

22 May 2018

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Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma

22 May 2018

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Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer

22 May 2018

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Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma

22 May 2018

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Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

22 May 2018

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LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

22 May 2018

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Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs

22 May 2018

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Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer

22 May 2018

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Ferroptosis as a p53-mediated activity during tumour suppression

22 May 2018

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Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

22 May 2018

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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

22 May 2018

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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

22 May 2018

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Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health.

22 May 2018

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Synthesis and preliminary biological evaluation of O-2((2-[(18)F]fluoroethyl)methylamino)ethyltyrosine ([(18)F]FEMAET) as a potential cationic amino acid PET tracer for tumor imaging.

22 May 2018

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The SLC38 family of sodium-amino acid co-transporters.

22 May 2018

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Glutaminase regulation in cancer cells: a druggable chain of events.

22 May 2018

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22 May 2018

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

22 May 2018

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Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity

22 May 2018

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Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling

22 May 2018

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A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells

22 May 2018

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mTOR signaling in growth control and disease

22 May 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

22 May 2018

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Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) Ligands with Novel Serine Analogs

22 May 2018

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

22 May 2018

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Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.

22 May 2018

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Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

22 May 2018

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

22 May 2018

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Hallmarks of Cancer: The Next Generation

22 May 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

22 May 2018

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A novel glutaminase isoform in mammalian tissues.

22 May 2018

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Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts

22 May 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

22 May 2018

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Bidirectional transport of amino acids regulates mTOR and autophagy

22 May 2018

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Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

22 May 2018

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Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans

22 May 2018

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Molecular mechanisms of glutamine action

22 May 2018

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Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19

22 May 2018

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Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance

22 May 2018

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Recent molecular advances in mammalian glutamine transport

22 May 2018

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Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

22 May 2018

1 reference

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Identification and purification of the reconstitutively active glutamine carrier from rat kidney mitochondria

22 May 2018

1 reference

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Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter

22 May 2018

1 reference

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Glutamine transport in submitochondrial particles

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770653

Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo

22 May 2018

1 reference

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Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs.

14 August 2018

1 reference

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Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy

14 August 2018

1 reference

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Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

14 August 2018

1 reference

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Right on TARGET: glutamine metabolism in cancer

14 August 2018

1 reference

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L-amino acid transporter 1 may be a prognostic marker for local progression of prostatic cancer under expectant management.

14 August 2018

1 reference

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Glutaminolysis and carcinogenesis of oral squamous cell carcinoma

14 August 2018

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Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770653

Transporters in drug development and clinical pharmacology

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770653

Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris--functional and kinetic asymmetry revealed in proteoliposomes

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770653

Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770653

Glutamine Transport in Normal and Acidotic Rat Kidney Mitochondria

14 August 2018

1 reference

12 December 2020

Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

1 reference

12 December 2020

Expression of human heteromeric amino acid transporters in the yeast Pichia pastoris

1 reference

12 December 2020

Transport mechanism and regulatory properties of the human amino acid transporter ASCT2 (SLC1A5)

1 reference

12 December 2020

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

1 reference

12 December 2020

Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma

1 reference

12 December 2020

Cysteine is not a substrate but a specific modulator of human ASCT2 (SLC1A5) transporter

1 reference

12 December 2020

Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.3389/FONC.2017.00306

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376023%20AND%20SRC:MED&resulttype=core&format=json

release_ml6x6jkuyfe4xervcxer7vcpwi

13 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ml6x6jkuyfe4xervcxer7vcpwi

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29376023%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

29376023

1 reference