Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. (Q39225768)

10 September 2017

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells (English)

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14 May 2020

6

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14 May 2020

Oliver D K Maddocks

1

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14 May 2020

Susan Mason

3

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14 May 2020

Karen Blyth

5

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7

Karen H Vousden

1 reference

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14 May 2020

author name string

Celia R Berkers

2

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14 May 2020

Liang Zheng

4

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14 May 2020

language of work or name

English

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publication date

16 December 2012

1 reference

10 September 2017

5

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inferred from page(s)

published in

Nature

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14 May 2020

volume

493

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14 May 2020

issue

7433

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page(s)

542-546

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https://scigraph.springernature.com/pub.10.1038/nature11743

14 May 2020

exact match

0 references

cites work

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

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https://api.crossref.org/works/10.1038%2FNATURE11743

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE11743

p53 regulates mitochondrial respiration

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE11743

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

21 January 2018

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

21 January 2018

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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE11743

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Metabolic regulation by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Dietary glycine inhibits the growth of B16 melanoma tumors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE11743

Metabolic control analysis of mammalian serine metabolism

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE11743

Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

21 January 2018

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Genetic selection for enhanced serine metabolism in cancer development.

21 January 2018

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Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

21 January 2018

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

21 January 2018

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Regulation of AIF expression by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein

21 January 2018

1 reference

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Cancer: Sacrifice for survival.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE11743

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE11743

Resurgence of serine: an often neglected but indispensable amino Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11743

Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23242140

12 December 2020

inferred from PubMed ID database lookup

Identification of seven genes regulated by wild-type p53 in a colon cancer cell line carrying a well-controlled wild-type p53 expression system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23242140

12 December 2020

inferred from PubMed ID database lookup

Glycolytic enzymes can modulate cellular life span

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23242140

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NATURE11743

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6485472&resulttype=core&format=json

Dimensions Publication ID

14 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6485472&resulttype=core&format=json

14 May 2020

1 reference