Colony stimulating factor 2 receptor subunit beta (Q5014088)

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mammalian protein found in Homo sapiens

beta-GM-CSF receptor
interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
colony stimulating factor 2 receptor beta common subunit
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF2RB
GM-CSF/IL-3/IL-5 receptor common beta-chain
cytokine receptor common subunit beta
colony-stimulating factor-2 receptor, beta, low-affinity
beta common cytokine receptor
GM-CSF/IL-3/IL-5 receptor common beta subunit
CDw131

Language	Label	Description	Also known as
English	Colony stimulating factor 2 receptor subunit beta	mammalian protein found in Homo sapiens	beta-GM-CSF receptor interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity) colony stimulating factor 2 receptor beta common subunit colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) CSF2RB GM-CSF/IL-3/IL-5 receptor common beta-chain cytokine receptor common subunit beta colony-stimulating factor-2 receptor, beta, low-affinity beta common cytokine receptor GM-CSF/IL-3/IL-5 receptor common beta subunit CDw131

Statements

1 reference

13 November 2019

UniProt protein ID

Fibronectin type III superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32927

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32927

Cytokine IL-3/IL-5/GM-CSF receptor common beta chain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32927

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Type I cytokine receptor, cytokine-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Short hematopoietin receptor, family 1, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Interferon/interleukin receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

interleukin-3 receptor activity

determination method

1 reference

8 April 2019

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

interleukin-5 receptor activity

determination method

1 reference

8 April 2019

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

protein binding

determination method

6 references

8 April 2019

CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

8 April 2019

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

8 April 2019

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

8 April 2019

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

8 April 2019

Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

8 April 2019

JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

cytokine receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

protein tyrosine kinase activity

determination method

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32927&geneProductId=UniProtKB:P32927

determination method

signaling receptor activity

determination method

1 reference

8 April 2019

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

determination method

2 references

plasma membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

integral component of plasma membrane

determination method

2 references

8 April 2019

Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

8 April 2019

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

granulocyte macrophage colony-stimulating factor receptor complex

determination method

1 reference

8 April 2019

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

intracellular anatomical structure

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32927&geneProductId=UniProtKB:P32927

determination method

biological process

respiratory gaseous exchange by respiratory system

determination method

1 reference

8 April 2019

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

signal transduction

determination method

response to lipopolysaccharide

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32927&geneProductId=UniProtKB:P32927

determination method

interleukin-5-mediated signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

cellular response to interleukin-3

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

interleukin-3-mediated signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32927

determination method

Commons category

CSF2RB

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000384053

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384053

ENSP00000385271

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385271

ENSP00000262825

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000262825

ENSP00000393585

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393585

0 references

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(3 entries)

enwiki CSF2RB
ruwiki CSF2RB
zhwiki CSF2RB

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:CSF2RB

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