CCCTC-binding factor (Q5014546)

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mammalian protein found in Homo sapiens

CCCTC-binding factor (zinc finger protein)
11 zinc finger transcriptional repressor
transcriptional repressor CTCF
11-zinc finger protein
CTCFL paralog
CTCF

Language	Label	Description	Also known as
English	CCCTC-binding factor	mammalian protein found in Homo sapiens	CCCTC-binding factor (zinc finger protein) 11 zinc finger transcriptional repressor transcriptional repressor CTCF 11-zinc finger protein CTCFL paralog CTCF

Statements

1 reference

13 November 2019

UniProt protein ID

Zinc finger C2H2 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49711

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein CTCF PDB 1x6h.png
628 × 540; 107 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription corepressor activity

determination method

1 reference

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

DNA-binding transcription factor activity

determination method

2 references

27 March 2018

A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

27 March 2018

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

zinc ion binding

determination method

1 reference

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

chromatin insulator sequence binding

determination method

1 reference

8 April 2019

Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

2 references

10 September 2018

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

protein binding

determination method

6 references

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

JARID1B is a luminal lineage-driving oncogene in breast cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

Vigilin interacts with CCCTC-binding factor (CTCF) and is involved in CTCF-dependent regulation of the imprinted genes Igf2 and H19

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

nucleic acid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

sequence-specific DNA binding

determination method

1 reference

27 March 2018

Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

chromatin binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

DNA-binding transcription factor activity

determination method

3 references

8 April 2019

A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

determination method

4 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

27 March 2018

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

27 March 2018

Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

27 March 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

determination method

1 reference

8 April 2019

Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

chromosome, centromeric region

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

CTCF physically links cohesin to chromatin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

condensed chromosome

determination method

1 reference

8 April 2019

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

regulation of gene expression, epigenetic

determination method

1 reference

8 April 2019

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

regulation of centromeric sister chromatid cohesion

determination method

1 reference

8 April 2019

CTCF physically links cohesin to chromatin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

chromosome segregation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

positive regulation of transcription, DNA-templated

determination method

negative regulation of transcription, DNA-templated

determination method

2 references

8 April 2019

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

protein localization to chromosome, centromeric region

determination method

1 reference

8 April 2019

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

chromatin organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

27 March 2018

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

positive regulation of gene expression

determination method

1 reference

27 March 2018

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

determination method

negative regulation of transcription by RNA polymerase II

determination method

2 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

DNA methylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

regulation of gene expression by genetic imprinting

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

maintenance of DNA methylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

regulation of histone methylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

regulation of histone acetylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

determination method

Gene Atlas image

PBB GE CTCF 202521 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P49711

1 reference

Identifiers.org

Zinc finger C2H2-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49711

Identifiers

MeSH descriptor ID

subject named as

CCCTC-Binding Factor

0 references

D12.776.157.687.157

0 references

D12.776.260.120

0 references

D12.776.660.235.050

0 references

D12.776.660.720.157

0 references

D12.776.664.235.050

0 references

D12.776.930.780.563

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264010

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264010

ENSP00000384707

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384707

ENSP00000494408

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494408

ENSP00000494538

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494538

ENSP00000493495

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493495

ENSP00000495218

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495218

ENSP00000495923

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495923

ENSP00000495115

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495115

ENSP00000495348

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495348

ENSP00000494443

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494443

ENSP00000494358

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494358

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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