The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis (Q50335521)

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scientific article published in November 2003

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English	The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis	scientific article published in November 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

author name string

Katia Coulonval

1

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PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

Laurence Bockstaele

2

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Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

Sabine Paternot

3

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

Jacques E Dumont

4

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PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

Pierre P Roger

5

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5 March 2018

http://europepmc.org/abstract/MED/14597415

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publication date

1 November 2003

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Europe PubMed Central

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5 March 2018

http://europepmc.org/abstract/MED/14597415

Experimental Cell Research

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5 March 2018

http://europepmc.org/abstract/MED/14597415

291

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Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

1

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Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

135-149

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Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

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Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

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Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

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Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

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Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

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10.1016/S0014-4827(03)00392-6

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 March 2018

http://europepmc.org/abstract/MED/14597415

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