Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects. (Q50421763)

13 March 2018

title

Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects. (English)

1 reference

13 March 2018

0 references

Ning Kon

1

1 reference

13 March 2018

Donglai Wang

2

1 reference

13 March 2018

Tongyuan Li

3

1 reference

13 March 2018

Le Jiang

4

1 reference

13 March 2018

Li Qiang

5

1 reference

13 March 2018

Wei Gu

6

1 reference

13 March 2018

language of work or name

English

0 references

publication date

2 January 2018

1 reference

13 March 2018

published in

Oncotarget

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13 March 2018

volume

9

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13 March 2018

page(s)

7282-7297

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13 March 2018

issue

7

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13 March 2018

Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure.

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22 May 2018

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Identification of small molecules affecting p53-MDM2/MDMX interaction by fluorescence polarization

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22 May 2018

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A critical role for noncoding 5S rRNA in regulating Mdmx stability

22 May 2018

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The impact of acetylation and deacetylation on the p53 pathway

22 May 2018

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Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

22 May 2018

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IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

22 May 2018

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Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity

22 May 2018

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22 May 2018

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22 May 2018

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New insights into p53 activation

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Inactivation of HAUSP in vivo modulates p53 function

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22 May 2018

Modes of p53 regulation

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Blinded by the Light: The Growing Complexity of p53

22 May 2018

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22 May 2018

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Acetylation is indispensable for p53 activation

22 May 2018

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

22 May 2018

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Distinct roles of MDMX in the regulation of p53 response to ribosomal stress

22 May 2018

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The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

22 May 2018

1 reference

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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

p53 regulates mitochondrial respiration

22 May 2018

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

22 May 2018

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22 May 2018

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

22 May 2018

1 reference

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Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Regulation of the p53 transcriptional activity.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Obesity and hepatocellular carcinoma

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Obesity is associated with macrophage accumulation in adipose tissue

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

MDMX: a novel p53-binding protein with some functional properties of MDM2

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800902

NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29484110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29484110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.23837

1 reference

13 March 2018

PMCID

5800902

1 reference

13 March 2018

PubMed ID

29484110

1 reference

13 March 2018