Validation of MdmX as a therapeutic target for reactivating p53 in tumors (Q34209099)

31 July 2017

title

Validation of MdmX as a therapeutic target for reactivating p53 in tumors (English)

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31 July 2017

5

Emmanuelle Passegué

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31 July 2017

Daniel Garcia

1

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31 July 2017

Matthew R Warr

2

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31 July 2017

Carla P Martins

3

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31 July 2017

Lamorna Brown Swigart

4

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31 July 2017

Gerard I Evan

6

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31 July 2017

publication date

1 August 2011

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31 July 2017

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31 July 2017

volume

25

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31 July 2017

issue

16

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31 July 2017

page(s)

1746-1757

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describes a project that uses

31 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3165938/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity

5 July 2018

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Puma is required for p53-induced depletion of adult stem cells

5 July 2018

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Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras

5 July 2018

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Puzzling over MDM4-p53 network

5 July 2018

1 reference

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A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

5 July 2018

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Identification and characterization of the first small molecule inhibitor of MDMX

5 July 2018

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Regulation of the p53 transcriptional response by structurally diverse core promoters

5 July 2018

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5 July 2018

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Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

5 July 2018

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Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases

5 July 2018

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5 July 2018

Modes of p53 regulation

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Blinded by the Light: The Growing Complexity of p53

5 July 2018

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Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival

5 July 2018

1 reference

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Mdm2 and Mdm4 loss regulates distinct p53 activities

5 July 2018

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5 July 2018

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

5 July 2018

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Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

5 July 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

5 July 2018

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Restoration of p53 function leads to tumour regression in vivo

5 July 2018

1 reference

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5 July 2018

1 reference

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Modeling the therapeutic efficacy of p53 restoration in tumors

5 July 2018

1 reference

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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

5 July 2018

1 reference

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Inactivation of the p53 pathway in retinoblastoma.

5 July 2018

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

5 July 2018

1 reference

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Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

5 July 2018

1 reference

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Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

5 July 2018

1 reference

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

5 July 2018

1 reference

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Mdmx as an essential regulator of p53 activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Tumor spectrum analysis in p53-mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Distinct roles of Mdm2 and Mdm4 in red cell production

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

p53 suppresses the self-renewal of adult neural stem cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Temporal dissection of p53 function in vitro and in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165938

Hdmx stabilizes Mdm2 and p53

28 October 2018

1 reference

12 December 2020

Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice

1 reference

12 December 2020

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

12 December 2020

Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death

1 reference

12 December 2020

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