The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q. (Q50453301)

14 March 2018

title

The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q. (English)

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14 March 2018

main subject

BAG cochaperone 5

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GOA release 2020-03-11

BAG cochaperone 2

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GOA release 2020-03-11

protein stabilization

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GOA release 2020-03-11

protein ubiquitination

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Xiang-Qian Che

1

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14 March 2018

Bei-Sha Tang

2

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14 March 2018

Hong-Feng Wang

3

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14 March 2018

Xin-Xiang Yan

4

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14 March 2018

Hong Jiang

5

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14 March 2018

Lu Shen

6

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14 March 2018

Qian Xu

7

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14 March 2018

Guang-Hui Wang

8

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14 March 2018

Hai-Nan Zhang

9

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14 March 2018

Chun-Yu Wang

10

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14 March 2018

Ji-Feng Guo

11

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14 March 2018

publication date

19 August 2014

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14 March 2018

International Journal of Neuroscience

published in

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14 March 2018

volume

125

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14 March 2018

issue

5

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14 March 2018

page(s)

390-394

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14 March 2018

Spinocerebellar ataxia 3 and Machado-Joseph disease: clinical, molecular, and neuropathological features.

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Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family

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Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3): a two-case report

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CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

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Ataxin-3 and its e3 partners: implications for machado-joseph disease

21 January 2018

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Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

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Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.

21 January 2018

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Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

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Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

21 January 2018

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The BAG proteins: a ubiquitous family of chaperone regulators

21 January 2018

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The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

The BAG2 protein stabilises PINK1 by decreasing its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00207454.2014.940585

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Regulation of the cytoplasmic quality control protein degradation pathway by BAG2

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00207454.2014.940585

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Parkin and Hsp70 sacked by BAG5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00207454.2014.940585

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00207454.2014.940585

Molecular clearance of ataxin-3 is regulated by a mammalian E4

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00207454.2014.940585

10.3109/00207454.2014.940585

21 January 2018

Identifiers

DOI

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14 March 2018

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14 March 2018