Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. (Q50469746)

14 March 2018

title

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. (English)

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14 March 2018

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Daniel Reker

1

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Bernd Schweizer

Bernd Schweizer

10

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Adelbert Bacher

12

Adelbert Bacher

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15

Gisbert Schneider

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14

François Diederich

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11

Boris Illarionov

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Markus Fischer

13

Markus Fischer

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Petra Schneider

5

Petra Schneider

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Matthias Rottmann

7

Matthias Rottmann

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author name string

Michael Seet

2

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Max Pillong

3

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Christian P Koch

4

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Matthias C Witschel

6

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Céline Freymond

8

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Reto Brun

9

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language of work or name

English

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publication date

4 June 2014

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Angewandte Chemie International Edition

published in

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volume

53

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issue

27

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page(s)

7079-7084

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Global malaria mortality between 1980 and 2010: a systematic analysis

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Thousands of chemical starting points for antimalarial lead identification

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Searching for drug scaffolds with 3D pharmacophores and neural network ensembles.

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When is chemical similarity significant? The statistical distribution of chemical similarity scores and its extreme values

21 January 2018

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Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity

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Self-organizing fuzzy graphs for structure-based comparison of protein pockets.

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Architectural repertoire of ligand-binding pockets on protein surfaces.

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Can mosquitoes be bitten? A new hope for anti-malarial drug design.

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Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue

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Targeting Plasmodium PI(4)K to eliminate malaria

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Protein kinases of malaria parasites: an update

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201311162

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14 March 2018

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14 March 2018