A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development. (Q50654081)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21151194%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development (English)

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18 January 2020

1

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18 January 2020

Sally L. Dunwoodie

5

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18 January 2020

Gavin Chapman

2

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18 January 2020

author name string

Yovina Sontani

3

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18 January 2020

Sharon E Pursglove

4

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18 January 2020

publication date

14 December 2010

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Immunology & Cell Biology

18 January 2020

published in

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18 January 2020

volume

89

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18 January 2020

issue

6

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18 January 2020

page(s)

696-705

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Notch signaling: cell fate control and signal integration in development

18 January 2020

cites work

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Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo

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The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

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Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification

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Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

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A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer

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Delta-like 4 is indispensable in thymic environment specific for T cell development

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Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

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Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling

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Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development

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CD45: a critical regulator of signaling thresholds in immune cells

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Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.

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A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

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Aire regulates negative selection of organ-specific T cells

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Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

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Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.

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Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

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High levels of Notch signaling down-regulate Numb and Numblike

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Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

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Notch regulation of lymphocyte development and function.

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Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation

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Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

21 January 2018

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An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila.

21 January 2018

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Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

21 January 2018

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Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.

21 January 2018

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Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

21 January 2018

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neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.

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The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

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The Notch regulator Numb links the Notch and TCR signaling pathways

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Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

21 January 2018

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Notch directly regulates Gata3 expression during T helper 2 cell differentiation

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Notch signaling is an important regulator of type 2 immunity.

21 January 2018

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The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

21 January 2018

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

21 January 2018

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Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis

21 January 2018

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Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype

21 January 2018

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Maintenance of neuroepithelial progenitor cells by Delta–Notch signalling in the embryonic chick retina

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inferred from DOI database lookup

7 January 2021

based on heuristic

Itch genetically interacts with Notch1 in a mouse autoimmune disease model

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inferred from DOI database lookup

7 January 2021

based on heuristic

Tracing the action of IL-2 in tolerance to islet-specific antigen

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