Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death. (Q50764411)

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13 January 2020

title

Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death (English)

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spinocerebellar ataxia type 14

13 January 2020

main subject

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1 reference

1

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13 January 2020

Naoko Adachi

2

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13 January 2020

Hideshi Kawakami

9

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Masayasu Matsumoto

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13 January 2020

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Norio Sakai

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13 January 2020

author name string

Yoshitaka Ono

3

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13 January 2020

Hideki Mochizuki

4

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13 January 2020

Keiko Hiramoto

5

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13 January 2020

Taku Amano

6

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13 January 2020

Hiroaki Matsubayashi

7

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13 January 2020

Naoaki Saito

10

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language of work or name

English

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publication date

17 June 2005

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Journal of Biological Chemistry

13 January 2020

published in

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volume

280

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issue

32

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page(s)

29096-29106

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Cerebellar/spinocerebellar syndromes

13 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Molecular basis of the neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Trinucleotide repeats and neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Protein kinase C gamma (PKC gamma): function of neuron specific isotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Studies and perspectives of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Membrane targeting by C1 and C2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Multiple pathways control protein kinase C phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Late-onset neurodegenerative diseases--the role of protein insolubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Threonine-497 is a critical site for permissive activation of protein kinase C alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Increases in intracellular calcium via activation of an endogenous P2-purinoceptor in cultured CHO-K1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Protein aggregation and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Regulation of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501716200

21 January 2018

Identifiers

DOI

10.1074/JBC.M501716200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15964845%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference