The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells. (Q50878921)

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scientific article published in January 2008

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English	The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells.	scientific article published in January 2008

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29 December 2019

The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells (English)

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29 December 2019

cell fate commitment

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Francesco Bertoni

6

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29 December 2019

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29 December 2019

3

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29 December 2019

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29 December 2019

Federica Sallusto

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Federica Sallusto

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29 December 2019

David Jarrossay

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David Jarrossay

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29 December 2019

Antonio Lanzavecchia

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Antonio Lanzavecchia

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29 December 2019

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Laura Lozza

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29 December 2019

Andrea Rinaldi

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29 December 2019

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1 January 2008

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29 December 2019

European Journal of Immunology

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29 December 2019

38

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29 December 2019

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29 December 2019

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29 December 2019

Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development

1 reference

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21 January 2018

Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells

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Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L.

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The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism

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Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein

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Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells.

1 reference

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21 January 2018

IL-7 enhances the survival and maintains the size of naive T cells

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Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

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Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells

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Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation

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Central memory and effector memory T cell subsets: function, generation, and maintenance

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T cell fitness determined by signal strength

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IL-7 promotes the transition of CD4 effectors to persistent memory cells

1 reference

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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

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Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells

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Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets

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Do CD8 effector cells need IL-7R expression to become resting memory cells?

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7 January 2021

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IL-7 receptor expression levels do not identify CD8+ memory T lymphocyte precursors following peptide immunization

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7 January 2021

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IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells.

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7 January 2021

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Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help

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Antigen-independent memory CD8 T cells do not develop during chronic viral infection

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Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells

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Deciphering the relationship between central and effector memory CD8+ T cells

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Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells.

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Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

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Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

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The emerging role of CTLA-4 as an immune attenuator

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Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells

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Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells

1 reference

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Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

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IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory

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Interleukin 7 regulates the survival and generation of memory CD4 cells

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

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IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes

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Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

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Lineage relationship and protective immunity of memory CD8 T cell subsets

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Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.

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Initial T cell frequency dictates memory CD8+ T cell lineage commitment

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Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

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