Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis. (Q50908536)

25 March 2018

title

Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis. (English)

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25 March 2018

8

Linzhao Cheng

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author name string

Yong Yu

1

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25 March 2018

Dan Liang

2

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Qing Tian

3

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Xiaona Chen

4

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Bo Jiang

5

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Bin-Kuan Chou

6

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Ping Hu

7

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Ping Gao

9

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Jinsong Li

10

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Gang Wang

11

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publication date

1 February 2014

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25 March 2018

published in

Stem Cells

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volume

32

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issue

2

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page(s)

349-363

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Generation of pluripotent stem cells from adult mouse liver and stomach cells

cites work

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Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression

21 January 2018

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Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency

21 January 2018

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A high-efficiency system for the generation and study of human induced pluripotent stem cells

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Reprogramming of pancreatic beta cells into induced pluripotent stem cells

21 January 2018

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A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

21 January 2018

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

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Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

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Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts

21 January 2018

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Generation of induced pluripotent stem cell lines from Tibetan miniature pig.

21 January 2018

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Generation of pig induced pluripotent stem cells with a drug-inducible system

21 January 2018

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BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

21 January 2018

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Vitamin C enhances the generation of mouse and human induced pluripotent stem cells

21 January 2018

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A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog

21 January 2018

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Wnt signaling promotes reprogramming of somatic cells to pluripotency

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds

21 January 2018

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Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

21 January 2018

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Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

21 January 2018

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miR-34 miRNAs provide a barrier for somatic cell reprogramming

21 January 2018

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Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.

21 January 2018

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Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc

21 January 2018

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Promotion of reprogramming to ground state pluripotency by signal inhibition

21 January 2018

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Suppression of induced pluripotent stem cell generation by the p53-p21 pathway

21 January 2018

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Linking the p53 tumour suppressor pathway to somatic cell reprogramming

21 January 2018

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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

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Direct cell reprogramming is a stochastic process amenable to acceleration

21 January 2018

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Role of ERas in promoting tumour-like properties in mouse embryonic stem cells

21 January 2018

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Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

Generation of induced pluripotent stem cells in the absence of drug selection

21 January 2018

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Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells

21 January 2018

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Generation of germline-competent induced pluripotent stem cells

21 January 2018

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Regulation of Nanog Expression by Phosphoinositide 3-Kinase-dependent Signaling in Murine Embryonic Stem Cells

21 January 2018

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AKT signaling promotes derivation of embryonic germ cells from primordial germ cells

21 January 2018

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Effects of Akt signaling on nuclear reprogramming.

21 January 2018

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Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development

21 January 2018

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Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors

21 January 2018

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Mediator MED23 links insulin signaling to the adipogenesis transcription cascade

21 January 2018

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Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells

21 January 2018

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Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse

21 January 2018

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A molecular roadmap of reprogramming somatic cells into iPS cells

21 January 2018

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Downregulation of the PI3K/Akt survival pathway in cells with deregulated expression of c-Myc

21 January 2018

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Tyrosine phosphatase SHP-2 dephosphorylates the platelet-derived growth factor receptor but enhances its downstream signalling

21 January 2018

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A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation.

21 January 2018

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Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway

21 January 2018

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 January 2018

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PI3K-AKT-FoxO axis in cancer and aging.

21 January 2018

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FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

21 January 2018

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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

21 January 2018

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BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

21 January 2018

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The Ink4/Arf locus is a barrier for iPS cell reprogramming

21 January 2018

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Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

21 January 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

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Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

21 January 2018

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Reprogramming of human primary somatic cells by OCT4 and chemical compounds

21 January 2018

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Stem cells: The promises and perils of p53.

21 January 2018

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Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis.

21 January 2018

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Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript.

21 January 2018

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Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells

21 January 2018

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Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer

21 January 2018

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Coexistence of quiescent and active adult stem cells in mammals

21 January 2018

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PTEN-deficient intestinal stem cells initiate intestinal polyposis

21 January 2018

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Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy

21 January 2018

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The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells

21 January 2018

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Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation

21 January 2018

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Elite and stochastic models for induced pluripotent stem cell generation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1447

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25 March 2018

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25 March 2018