FOXO1 is an essential regulator of pluripotency in human embryonic stem cells (Q33740977)

29 July 2017

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells (English)

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human embryonic stem cell

29 July 2017

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29 July 2017

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Thomas Tuschl

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29 July 2017

Dung-Fang Lee

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Gordon M. Keller

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Gordon Keller

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author name string

Xin Zhang

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29 July 2017

Safak Yalcin

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29 July 2017

Tsung-Yin J Yeh

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29 July 2017

Seung-Min Lee

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29 July 2017

Jie Su

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29 July 2017

Sathish Kumar Mungamuri

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29 July 2017

Pauline Rimmelé

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29 July 2017

Marion Kennedy

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29 July 2017

Rani Sellers

10

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29 July 2017

Nai-Wen Chi

13

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29 July 2017

Ihor Lemischka

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29 July 2017

Saghi Ghaffari

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29 July 2017

31 July 2011

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1092-1099

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https://scigraph.springernature.com/pub.10.1038/ncb2293

29 July 2017

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cites work

Regulation and function of FoxO transcription factors in normal and cancer stem cells: what have we learned?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Integrating opposing signals toward Forkhead box O.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

FoxO3 regulates neural stem cell homeostasis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Naive and primed pluripotent states

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

REST maintains self-renewal and pluripotency of embryonic stem cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Induced pluripotent stem cell lines derived from human somatic cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Foxo3 is required for the regulation of oxidative stress in erythropoiesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

How is pluripotency determined and maintained?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Molecular control of pluripotency

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Dissecting self-renewal in stem cells with RNA interference

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Regulatory networks in embryo-derived pluripotent stem cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Core transcriptional regulatory circuitry in human embryonic stem cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Embryonic stem cell differentiation: emergence of a new era in biology and medicine

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Multipotent cell lineages in early mouse development depend on SOX2 function

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

TCL1 participates in early embryonic development and is overexpressed in human seminomas

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Direct control of the Forkhead transcription factor AFX by protein kinase B

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

14 July 2018

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Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.

21 January 2018

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ERK and MDM2 prey on FOXO3a.

21 January 2018

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Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

21 January 2018

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A core Klf circuitry regulates self-renewal of embryonic stem cells.

21 January 2018

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Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

21 January 2018

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Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment

21 January 2018

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Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053529

30 October 2018

Identifiers

DOI

10.1038/NCB2293

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Dimensions Publication ID

29 July 2017

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29 July 2017

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