Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. (Q50970521)

PubMed publication ID

23697945

26 March 2018

http://europepmc.org/abstract/MED/23697945

title

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity (English)

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13 May 2020

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1

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Marcus Conrad

7

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13 May 2020

Chi Chen

8

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13 May 2020

author name string

Bradley A Carlson

2

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13 May 2020

Fei Li

3

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13 May 2020

Jessica A Bonzo

4

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13 May 2020

Min-Hyuk Yoo

5

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Kristopher W Krausz

6

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13 May 2020

Frank J Gonzalez

9

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Dolph L Hatfield

10

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publication date

7 June 2013

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PubMed publication ID

23697945

26 March 2018

http://europepmc.org/abstract/MED/23697945

published in

Chemical Research in Toxicology

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13 May 2020

volume

26

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issue

7

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13 May 2020

page(s)

1088-1096

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Acetaminophen toxicity. Opposite effects of two forms of glutathione peroxidase.

13 May 2020

cites work

1 reference

12 December 2020

Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione

1 reference

12 December 2020

Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events.

1 reference

12 December 2020

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

1 reference

12 December 2020

The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy

1 reference

12 December 2020

Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development

1 reference

12 December 2020

Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver

1 reference

12 December 2020

Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity

1 reference

12 December 2020

Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity

1 reference

12 December 2020

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

1 reference

12 December 2020

Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis

1 reference

12 December 2020

Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice

1 reference

12 December 2020

Thioredoxin and protein kinases in redox signaling.

1 reference

12 December 2020

The thioredoxin system in cancer-introduction to a thematic volume of Seminars in Cancer Biology

1 reference

12 December 2020

Impact of Cu, Zn-superoxide dismutase and Se-dependent glutathione peroxidase-1 knockouts on acetaminophen-induced cell death and related signaling in murine liver

1 reference

12 December 2020

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

1 reference

12 December 2020

Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury

1 reference

12 December 2020

Metabolic regulation and function of glutathione peroxidase-1.

1 reference

12 December 2020

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

1 reference

12 December 2020

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation

1 reference

12 December 2020

Glutathione in liver diseases and hepatotoxicity

1 reference

12 December 2020

Acetaminophen hepatotoxicity and acute liver failure

1 reference

12 December 2020

Selenoproteins that function in cancer prevention and promotion

1 reference

12 December 2020

Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes

1 reference

12 December 2020

Apoptosis and glutathione: beyond an antioxidant.

1 reference

12 December 2020

Comparative impacts of knockouts of two antioxidant enzymes on acetaminophen-induced hepatotoxicity in mice

1 reference

12 December 2020

Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1.

1 reference

12 December 2020

Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents.

1 reference

12 December 2020

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria

1 reference

12 December 2020

System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency

1 reference

12 December 2020

Gamma-glutamyltransferase of cancer cells at the crossroads of tumor progression, drug resistance and drug targeting

1 reference

12 December 2020

Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets

1 reference

12 December 2020

Characterization of protein targets of mammalian thioredoxin reductases

1 reference

12 December 2020

Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation

1 reference

12 December 2020

Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus

1 reference

12 December 2020

Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1.

1 reference

12 December 2020

Cellular redox pathways as a therapeutic target in the treatment of cancer

1 reference

12 December 2020

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice

1 reference

12 December 2020

Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury

1 reference

12 December 2020

Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis

1 reference

12 December 2020

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

1 reference

12 December 2020

Formation of a thiomethyl metabolite of phenacetin and acetaminophen in dogs and man

1 reference

12 December 2020

3-thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol

1 reference

12 December 2020

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

1 reference

12 December 2020

Identifiers

DOI

10.1021/TX4001013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6334300&resulttype=core&format=json

13 May 2020

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13 May 2020

PubMed publication ID

23697945

1 reference