Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. (Q50973704)

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20 January 2020

title

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial (English)

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20 January 2020

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5

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20 January 2020

Ly-Mee Yu

8

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20 January 2020

Paul T. Francis

10

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20 January 2020

Clive Ballard

13

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20 January 2020

Anne Corbett

6

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20 January 2020

3

Nicola Williams

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20 January 2020

1

Marisa Hanney

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20 January 2020

author name string

Vee Prasher

2

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20 January 2020

Emma L Jones

4

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20 January 2020

Dale Lawrence

7

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20 January 2020

Stephen Tyrer

9

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20 January 2020

Tony Johnson

11

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20 January 2020

Roger Bullock

12

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20 January 2020

MEADOWS trial researchers

14

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20 January 2020

language of work or name

English

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publication date

10 January 2012

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20 January 2020

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20 January 2020

volume

379

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20 January 2020

issue

9815

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20 January 2020

page(s)

528-536

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Cognitive decline in Down syndrome.

20 January 2020

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Fifteen-year follow-up of 92 hospitalized adults with Down's syndrome: incidence of cognitive decline, its relationship to age and neuropathology.

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Incidence and course of dementia in people with Down's syndrome: findings from a population-based study.

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Trends in Down's syndrome live births and antenatal diagnoses in England and Wales from 1989 to 2008: analysis of data from the National Down Syndrome Cytogenetic Register

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Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome

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Change in plasma Aß peptides and onset of dementia in adults with Down syndrome

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The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

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The Extended Tau Haplotype and the Age of Onset of Dementia in Down Syndrome

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7 January 2021

Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains

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7 January 2021

Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease--a unified glutamatergic hypothesis on the mechanism of action.

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Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome.

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7 January 2021

Redox regulation of neuronal migration in a Down Syndrome model

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7 January 2021

Altered glutamate uptake in peripheral tissues from Down syndrome patients.

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7 January 2021

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

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7 January 2021

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

1 reference

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7 January 2021

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

1 reference

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7 January 2021

Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome

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7 January 2021

Molecular and cellular mechanisms elucidating neurocognitive basis of functional impairments associated with intellectual disability in Down syndrome

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7 January 2021