Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. (Q51014106)

25 June 2018

title

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. (English)

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25 June 2018

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Jose M Irimia

1

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25 June 2018

Catalina M Meyer

2

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25 June 2018

Dyann M Segvich

3

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25 June 2018

Sneha Surendran

4

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25 June 2018

Anna A DePaoli-Roach

5

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25 June 2018

Nuria Morral

6

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25 June 2018

Peter J Roach

7

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25 June 2018

language of work or name

English

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publication date

8 May 2017

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25 June 2018

number of pages

10

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Journal of Biological Chemistry

inferred from page(s)

published in

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25 June 2018

volume

292

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25 June 2018

issue

25

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25 June 2018

page(s)

10455-10464

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25 June 2018

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

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IRS1-independent defects define major nodes of insulin resistance

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Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis

30 June 2018

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Selective versus total insulin resistance: a pathogenic paradox

30 June 2018

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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

30 June 2018

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30 June 2018

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Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis

30 June 2018

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Hepatic glycogen synthase deficiency: an infrequently recognized cause of ketotic hypoglycemia

30 June 2018

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30 June 2018

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Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

30 June 2018

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

30 June 2018

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A new mathematical model for relative quantification in real-time RT-PCR

30 June 2018

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Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.

30 June 2018

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30 June 2018

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Contraction-stimulated muscle glucose transport and GLUT-4 surface content are dependent on glycogen content

30 June 2018

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Novel aspects of the regulation of glycogen storage.

30 June 2018

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A noninvasive method to measure splanchnic glucose uptake after oral glucose administration

30 June 2018

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Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity.

30 June 2018

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Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus

30 June 2018

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Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a.

14 August 2018

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Glucose metabolism in mice lacking muscle glycogen synthase

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5481557

Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5481557

Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise

14 August 2018

1 reference

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Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5481557

Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5481557

Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5481557

Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets

14 August 2018

1 reference

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A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

14 August 2018

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12 December 2020

Muscle glycogen content affects insulin-stimulated glucose transport and protein kinase B activity

1 reference

12 December 2020

Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M117.786525

1 reference

25 June 2018

PMC publication ID

5481557

1 reference

25 June 2018

PubMed publication ID

28483921

1 reference

25 June 2018