Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production (Q37008856)

17 August 2017

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production (English)

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17 August 2017

0 references

1 reference

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238637%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Paul M Titchenell

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238637%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

William J Quinn

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1 reference

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7 June 2020

Mingjian Lu

3

1 reference

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7 June 2020

Qingwei Chu

4

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7 June 2020

Wenyun Lu

5

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7 June 2020

Changhong Li

6

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7 June 2020

Helen Chen

7

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7 June 2020

Bobby R Monks

8

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7 June 2020

Julia Chen

9

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7 June 2020

Joshua D Rabinowitz

10

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7 June 2020

publication date

26 May 2016

1 reference

17 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238637%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

23

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7 June 2020

page(s)

1154-1166

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7 June 2020

issue

6

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FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

7 June 2020

cites work

1 reference

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Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

29 September 2017

1 reference

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Decreased expression of hepatic glucokinase in type 2 diabetes.

29 September 2017

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Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

29 September 2017

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Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors.

29 September 2017

1 reference

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Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis

29 September 2017

1 reference

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

29 September 2017

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Strategies for the design of hepatoselective glucokinase activators to treat type 2 diabetes

29 September 2017

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29 September 2017

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Regulation of hepatic glucose uptake and storage in vivo

29 September 2017

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Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production

29 September 2017

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FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c

29 September 2017

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29 September 2017

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Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice

29 September 2017

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Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c

29 September 2017

1 reference

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Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

29 September 2017

1 reference

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Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

29 September 2017

1 reference

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Metabolomic analysis and visualization engine for LC-MS data

29 September 2017

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Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer

29 September 2017

1 reference

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mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

29 September 2017

1 reference

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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

29 September 2017

1 reference

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Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

29 September 2017

1 reference

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Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

29 September 2017

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Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats

29 September 2017

1 reference

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

29 September 2017

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Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation

29 September 2017

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Selective versus total insulin resistance: a pathogenic paradox

29 September 2017

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Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism

29 September 2017

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Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

29 September 2017

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29 September 2017

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29 September 2017

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Hypothalamic K(ATP) channels control hepatic glucose production

29 September 2017

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29 September 2017

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29 September 2017

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

29 September 2017

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29 September 2017

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Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs

29 September 2017

1 reference

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Correction of diabetic alterations by glucokinase.

29 September 2017

1 reference

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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

29 September 2017

1 reference

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Insulin's direct effects on the liver dominate the control of hepatic glucose production

27 June 2018

1 reference

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A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition

27 June 2018

1 reference

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Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

4 September 2018

1 reference

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Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

4 September 2018

1 reference

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Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice.

4 September 2018

1 reference

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A glucose sensor role for glucokinase in anterior pituitary cells.

4 September 2018

1 reference

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Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry.

4 September 2018

1 reference

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FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.

4 September 2018

1 reference

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Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

4 September 2018

1 reference

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Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression

4 September 2018

1 reference

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Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin

4 September 2018

1 reference

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The direct and indirect effects of insulin on hepatic glucose production in vivo

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27238637

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2016.04.022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238637%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238637%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference