Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems. (Q51020126)

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scientific article published on 27 October 2014

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English	Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems.	scientific article published on 27 October 2014

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scholarly article

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems. (English)

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

author name string

W Sangrar

1

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

C Shi

2

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

G Mullins

3

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

D LeBrun

4

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

B Ingalls

5

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

P A Greer

6

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

language of work or name

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publication date

27 October 2014

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

34

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Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

31

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Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

4109-4117

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Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

https://scigraph.springernature.com/pub.10.1038/onc.2014.340

0 references

ERBB receptors and cancer: the complexity of targeted inhibitors

1 reference

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21 January 2018

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

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Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer

1 reference

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Targeting the mitogen-activated protein kinase cascade to treat cancer

1 reference

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Endocytosis and intracellular trafficking of ErbBs

1 reference

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21 January 2018

Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation

1 reference

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21 January 2018

EGF-ERBB signalling: towards the systems level

1 reference

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HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells

1 reference

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Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

1 reference

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Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

1 reference

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21 January 2018

The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors

1 reference

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Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation

1 reference

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A quantitative protein interaction network for the ErbB receptors using protein microarrays

1 reference

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Closing in on the biological functions of Fps/Fes and Fer

1 reference

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Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion

1 reference

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FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance

1 reference

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21 January 2018

A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton

1 reference

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21 January 2018

Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.340

21 January 2018

Structural basis of membrane invagination by F-BAR domains

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.340

21 January 2018

Disruption of coiled-coil domains in Fer protein-tyrosine kinase abolishes trimerization but not kinase activation.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.340

21 January 2018

Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer

1 reference

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The roles of phospholipase D in EGFR signaling

1 reference

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Resiliency and vulnerability in the HER2-HER3 tumorigenic driver

1 reference

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Control of EGF receptor signaling by clathrin-mediated endocytosis.

1 reference

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Stabilization of clathrin coated vesicles by amantadine, tromantadine and other hydrophobic amines

1 reference

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Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane

1 reference

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Endocytosis and spatial restriction of cell signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.340

21 January 2018

Pathways of clathrin-independent endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.340

21 January 2018

Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells

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21 January 2018

The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly

1 reference

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Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP

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Requirement for the adapter protein GRB2 in EGF receptor endocytosis

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Grb2 regulates internalization of EGF receptors through clathrin-coated pits

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The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase

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An ultrasensitive sorting mechanism for EGF receptor endocytosis

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The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration

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Cell senescence and hypermitogenic arrest

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity.

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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

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An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

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An identity crisis for fps/fes: oncogene or tumor suppressor?

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Large-scale screening assay to measure epidermal growth factor internalization

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Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells

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Increased phosphotyrosine content and inhibition of proliferation in EGF-treated A431 cells

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Quantitative analysis of endocytosis and turnover of epidermal growth factor (EGF) and EGF receptor

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Identifiers

10.1038/ONC.2014.340

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

1 reference

Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/25347743

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