Optimization of heterologous production of the polyketide 6-MSA in Saccharomyces cerevisiae. (Q51093627)

29 March 2018

title

Optimization of heterologous production of the polyketide 6-MSA in Saccharomyces cerevisiae. (English)

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Phosphopantetheinyl transferase with a role in transferring a 4'-phosphopantetheine prosthetic group to non-ribosomal peptide synthases

main subject

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Saccharomyces cerevisiae

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Jens Nielsen

5

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author name string

Songsak Wattanachaisaereekul

1

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Anna Eliasson Lantz

2

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Michael Lynge Nielsen

3

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Olafur S Andrésson

4

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publication date

1 July 2007

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Biotechnology and Bioengineering

published in

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volume

97

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issue

4

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page(s)

893-900

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

cites work

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The multifunctional 6-methylsalicylic acid synthase gene of Penicillium patulum. Its gene structure relative to that of other polyketide synthases

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Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)

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Multifunctional yeast high-copy-number shuttle vectors

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6-Methylsalicylic acid synthetase from Penicillium patulum. Some catalytic properties of the enzyme and its relation to fatty acid synthetase

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Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5.

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Biosynthesis of nonribosomal peptides1.

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Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase.

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Multiple sequence alignment with Clustal X

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Changes of in vivo fluxes through central metabolic pathways during the production of nystatin by Streptomyces noursei in batch culture

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Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity

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Polyketide synthesis: prospects for hybrid antibiotics

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Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts

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A new enzyme superfamily - the phosphopantetheinyl transferases

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The developmentally regulated Aspergillus nidulans wA gene encodes a polypeptide homologous to polyketide and fatty acid synthases

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Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

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Structure-based mutational analysis of the 4'-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism

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Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression

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Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae.

21 January 2018

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4?-Phosphopantetheinyl transferase-encoding npgA is essential for siderophore biosynthesis in Aspergillus nidulans

21 January 2018

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Crystal structure of the surfactin synthetase-activating enzyme sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily

21 January 2018

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Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae

21 January 2018

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4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

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The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation

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Identifiers

DOI

10.1002/BIT.21286

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29 March 2018

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