Hopscotch Dmel_CG1594 (Q51236137)

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Protein found in Drosophila melanogaster

CG1594-PA
hop-PA
hop
locus 18
CG1594 gene product from transcript CG1594-RA
hopscotch
JAK kinase
Janus-family kinase
janus kinase
hopskotch
tumorous

Language	Label	Description	Also known as
English	Hopscotch Dmel_CG1594	Protein found in Drosophila melanogaster	CG1594-PA hop-PA hop locus 18 CG1594 gene product from transcript CG1594-RA hopscotch JAK kinase Janus-family kinase janus kinase hopskotch tumorous

Statements

1 reference

25 May 2022

UniProt protein ID

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Band 4.1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

protein tyrosine kinase activity

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

non-membrane spanning protein tyrosine kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

signaling receptor binding

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

cytokine receptor binding

determination method

1 reference

8 April 2019

Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

determination method

2 references

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

determination method

1 reference

8 April 2019

The JAK-STAT pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

cytoplasmic side of plasma membrane

determination method

1 reference

8 April 2019

Polarized subcellular localization of Jak/STAT components is required for efficient signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

endomembrane system

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

extrinsic component of cytoplasmic side of plasma membrane

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

biological process

compound eye morphogenesis

determination method

1 reference

8 April 2019

Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

compound eye photoreceptor cell differentiation

determination method

1 reference

8 April 2019

The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

apical constriction

determination method

1 reference

8 April 2019

Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

transcription, DNA-templated

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

regulation of transcription, DNA-templated

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

immune response

determination method

1 reference

8 April 2019

The evolution and genetics of innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

humoral immune response

determination method

1 reference

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

receptor signaling pathway via JAK-STAT

determination method

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

24 April 2018

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

24 April 2018

The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

24 April 2018

The fertile field of Drosophila Jak/STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

24 April 2018

Eye transformer is a negative regulator of Drosophila JAK/STAT signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

24 April 2018

Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

periodic partitioning

determination method

1 reference

8 April 2019

Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

nervous system development

determination method

1 reference

8 April 2019

Patterns and functions of STAT activation during Drosophila embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

eye-antennal disc morphogenesis

determination method

1 reference

8 April 2019

JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

primary sex determination

determination method

1 reference

8 April 2019

The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

long-term memory

determination method

1 reference

8 April 2019

Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

ommatidial rotation

determination method

1 reference

8 April 2019

The JAK/STAT pathway and Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

regulation of embryonic cell shape

determination method

1 reference

8 April 2019

Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

stem cell population maintenance

determination method

1 reference

8 April 2019

Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

ovarian follicle cell development

determination method

1 reference

8 April 2019

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

ovarian follicle cell stalk formation

determination method

1 reference

8 April 2019

Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

positive regulation of heterochromatin assembly

determination method

1 reference

8 April 2019

Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

larval lymph gland hemopoiesis

determination method

1 reference

8 April 2019

The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

lamellocyte differentiation

determination method

1 reference

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

hemocyte proliferation

determination method

1 reference

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

regulation of hemocyte proliferation

determination method

1 reference

8 April 2019

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

peptidyl-tyrosine autophosphorylation

determination method

1 reference

8 April 2019

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

establishment of ommatidial planar polarity

determination method

1 reference

8 April 2019

The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

germ-line stem cell division

determination method

1 reference

8 April 2019

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

hemocyte differentiation

determination method

1 reference

8 April 2019

The Hopscotch Jak kinase requires the Raf pathway to promote blood cell activation and differentiation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

innate immune response

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

locomotor rhythm

determination method

1 reference

8 April 2019

Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

regulation of hemocyte differentiation

determination method

1 reference

10 September 2018

A directed screen for genes involved in Drosophila blood cell activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

regulation of receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

somatic stem cell division

determination method

1 reference

8 April 2019

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

determination method

1 reference

5 June 2018

The fertile field of Drosophila Jak/STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

determination method

mediolateral intercalation

determination method

1 reference

8 April 2019

Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

receptor signaling pathway via JAK-STAT

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

Eye transformer is a negative regulator of Drosophila JAK/STAT signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

8 April 2019

Identification of JAK/STAT signalling components by genome-wide RNA interference.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

border follicle cell migration

determination method

1 reference

8 April 2019

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

wing disc morphogenesis

determination method

1 reference

8 April 2019

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

leg disc morphogenesis

determination method

1 reference

8 April 2019

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

haltere disc morphogenesis

determination method

1 reference

8 April 2019

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

determination method

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

Band 4.1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24592

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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