The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes. (Q51360789)

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scientific article published on 21 February 2012

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English	The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.	scientific article published on 21 February 2012

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23 January 2020

The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes (English)

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23 January 2020

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insulin resistance

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metabolic trait

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Johanne Marie Justesen

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Daniel R. Witte

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Torben Jørgensen

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Louise T Dalgaard

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Oluf Borbye Pedersen

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G Andersen

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S Anthonsen

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L W Thørner

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J O Clausen

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T Lauritzen

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J Holmkvist

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21 February 2012

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International Journal of Obesity

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175-181

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23 January 2020

https://scigraph.springernature.com/pub.10.1038/ijo.2012.22

0 references

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes

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https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366)

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis

1 reference

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21 January 2018

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Impact of uncoupling protein-2 overexpression on proinsulin processing

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Mutational analysis of the UCP2 core promoter and relationships of variants with obesity

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Variants of uncoupling protein-2 gene and obesity: interaction with peroxisome proliferator-activated receptorgamma2.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

A common polymorphism of uncoupling protein 2 gene is associated with hypertension.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

The common -866 G/A polymorphism in the promoter of uncoupling protein 2 is associated with increased carbohydrate and decreased lipid oxidation in juvenile obesity.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

European differences in the association between the UCP2 -866G > A common gene variant and markers of body mass and fasting plasma insulin.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

No evidence for involvement of the promoter polymorphism -866 G/A of the UCP2 gene in childhood-onset obesity in humans.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Uncoupling proteins: role in insulin resistance and insulin insufficiency

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Uncoupling proteins, dietary fat and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Genetic prediction of future type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

UCP2 -866G/A and Ala55Val, and UCP3 -55C/T polymorphisms in association with type 2 diabetes susceptibility: a meta-analysis study.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance.

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21 January 2018

Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Public health methods--attributable risk as a link between causality and public health action

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

A common polymorphism in the promoter of UCP2 is associated with obesity and hyperinsulenemia in northern Indians

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Combined analyses of 20 common obesity susceptibility variants

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Reactive oxygen species have a causal role in multiple forms of insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational Study.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Physiological relationships of uncoupling protein-2 gene expression in human adipose tissue in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

21 January 2018

Association between obesity and insulin resistance with UCP2–UCP3 gene variants in Spanish children and adolescents

1 reference

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21 January 2018

Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians

1 reference

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21 January 2018

Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1alpha p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

7 January 2021

based on heuristic

inferred from DOI database lookup

The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

7 January 2021

based on heuristic

inferred from DOI database lookup

Uncoupling protein 2: Adiposity angel and diabetes devil?

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2012.22

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/IJO.2012.22

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23 January 2020

release_p32p7zn3yvarvila642dmum7nm

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24 November 2022

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mapped directly with Wikidata item

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23 January 2020

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