Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis. (Q51430102)

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scientific article published on 4 October 2016

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English	Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis.	scientific article published on 4 October 2016

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scholarly article

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Europe PubMed Central

5 April 2018

http://europepmc.org/abstract/PMC/5306499

Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis. (English)

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Europe PubMed Central

5 April 2018

http://europepmc.org/abstract/PMC/5306499

cholecystokinin

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9

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1 June 2020

Bryony N Parsons

4

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Reidar Fossmark

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1 June 2020

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Malcolm Boyce

1

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1 June 2020

Andrew R Moore

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1 June 2020

Liv Sagatun

3

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Andrea Varro

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Fiona Campbell

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Helge L Waldum

8

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publication date

4 October 2016

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http://europepmc.org/abstract/PMC/5306499

British Journal of Clinical Pharmacology

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83

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1 June 2020

3

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1 June 2020

466-475

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1 June 2020

Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1.

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The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

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The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

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MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer

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Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration.

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22 May 2018

Gastric neuroendocrine tumors: prevalence in Europe, USA, and Japan, and rationale for treatment with a gastrin/CCK2 receptor antagonist

1 reference

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22 May 2018

Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects.

1 reference

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Lanreotide in metastatic enteropancreatic neuroendocrine tumors

1 reference

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Novel roles of gastrin

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Phenotype, origin and estimated prevalence of a common long QT syndrome mutation: a clinical, genealogical and molecular genetics study including Swedish R518X/KCNQ1 families

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22 May 2018

Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors

1 reference

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Metastatic type 1 gastric carcinoid: a real threat or just a myth?

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22 May 2018

Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis

1 reference

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22 May 2018

Autoimmune atrophic gastritis--pathogenesis, pathology and management

1 reference

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22 May 2018

Netazepide, a gastrin/CCK2 receptor antagonist, causes dose-dependent, persistent inhibition of the responses to pentagastrin in healthy subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5306499

22 May 2018

Systematic review: gastric cancer incidence in pernicious anaemia

1 reference

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22 May 2018

Long-term follow-up of a large series of patients with type 1 gastric carcinoid tumors: data from a multicenter study.

1 reference

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22 May 2018

Iron-deficiency anaemia, gastric hyperplasia, and elevated gastrin levels due to potassium channel dysfunction in the Jervell and Lange-Nielsen Syndrome

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22 May 2018

ENETS Consensus Guidelines for the management of patients with gastroduodenal neoplasms

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22 May 2018

Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms

1 reference

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22 May 2018

Diagnosis and management of pernicious anemia.

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22 May 2018

Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells.

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22 May 2018

p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.

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NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas

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Laparoscopic antrectomy for the treatment of type I gastric carcinoid tumors

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Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling.

1 reference

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22 May 2018

Gastrin - active participant or bystander in gastric carcinogenesis?

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22 May 2018

Review article: Pathogenesis and management of gastric carcinoid tumours.

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22 May 2018

Gastric carcinoids: a temporal increase with proton pump introduction.

1 reference

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22 May 2018

Gastrin: old hormone, new functions

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5306499

22 May 2018

Cholecystokinin antagonists: pharmacological and therapeutic potential

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5306499

22 May 2018

The gastrins: their production and biological activities

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Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia

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22 May 2018

Effects of YF476, a potent and selective gastrin/cholecystokinin-B receptor antagonist, on gastric acid secretion in beagle dogs with gastric fistula.

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Marked increase in gastric acid secretory capacity after omeprazole treatment

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22 May 2018

Intermittent treatment of recurrent type-1 gastric carcinoids with somatostatin analogues in patients with chronic autoimmune atrophic gastritis.

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Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour.

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14 August 2018

Treatment of gastric carcinoids type 1 with the gastrin receptor antagonist netazepide (YF476) results in regression of tumours and normalisation of serum chromogranin A.

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14 August 2018

Single oral doses of netazepide (YF476), a gastrin receptor antagonist, cause dose-dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects.

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Prevalence, mutation spectrum, and cardiac phenotype of the Jervell and Lange-Nielsen syndrome in Sweden

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Type I gastric carcinoids: a prospective study on endoscopic management and recurrence rate

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14 August 2018

Elevated serum gastrin levels in Jervell and Lange-Nielsen syndrome: a marker of severe KCNQ1 dysfunction?

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The CCK(2) receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development

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14 August 2018

Long-acting somatostatin analogues are an effective treatment for type 1 gastric carcinoid tumours.

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Treatment of ECL cell carcinoids with octreotide LAR.

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14 August 2018

A 50-year analysis of 562 gastric carcinoids: small tumor or larger problem?

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Spontaneous ECL cell carcinomas in cotton rats: natural course and prevention by a gastrin receptor antagonist.

1 reference

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Serum chromogranin A as a screening test for gastric enterochromaffin-like cell hyperplasia during acid-suppressive therapy.

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Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study

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12 December 2020

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Effect of cholecystokinin-2 receptor blockade on rat stomach ECL cells. A histochemical, electron-microscopic and chemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/27704617

12 December 2020

based on heuristic

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Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis, enterochromaffin-like cell lesions and gastric carcinoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/27704617

12 December 2020

based on heuristic

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Rapid regression of enterochromaffinlike cell gastric carcinoids in pernicious anemia after antrectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27704617

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based on heuristic

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Gastrin-induced apoptosis contributes to carcinogenesis in the stomach

1 reference

https://pubmed.ncbi.nlm.nih.gov/27704617

12 December 2020

based on heuristic

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Identifiers

10.1111/BCP.13146

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27704617%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27704617%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27704617%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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