Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer's Disease. (Q51533022)

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scientific article published on 5 September 2016

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English	Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer's Disease.	scientific article published on 5 September 2016

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scholarly article

1 reference

Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer's Disease. (English)

1 reference

Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

Caenorhabditis elegans

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based on heuristic

inferred from title

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based on heuristic

inferred from title

1

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Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

2

1 reference

Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

publication date

5 September 2016

1 reference

Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

Molecular Neurobiology

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Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

54

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Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

5427-5439

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Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

7

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Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

https://scigraph.springernature.com/pub.10.1007/s12035-016-0085-y

0 references

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

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21 January 2018

Intracellular amyloid-beta in Alzheimer's disease

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21 January 2018

Aberrant insulin signaling in Alzheimer's disease: current knowledge

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21 January 2018

Insulin and Alzheimer's disease: untangling the web.

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21 January 2018

The role of type 2 diabetes in neurodegeneration

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21 January 2018

Insulin resistance and cognitive dysfunction

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https://api.crossref.org/works/10.1007%2FS12035-016-0085-Y

21 January 2018

Overlapped metabolic and therapeutic links between Alzheimer and diabetes.

1 reference

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21 January 2018

Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease

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Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease - How Anti-Diabetics Could be a Solution for Dementia

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21 January 2018

Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress

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21 January 2018

Type 2 diabetes mellitus and Alzheimer's disease

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21 January 2018

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

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21 January 2018

Molecular mechanism of action of metformin: old or new insights?

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Metformin--mode of action and clinical implications for diabetes and cancer

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Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.

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21 January 2018

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation

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21 January 2018

Increased risk of cognitive impairment in patients with diabetes is associated with metformin

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Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study

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21 January 2018

The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex

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21 January 2018

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

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https://api.crossref.org/works/10.1007%2FS12035-016-0085-Y

21 January 2018

Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

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21 January 2018

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

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21 January 2018

A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau.

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21 January 2018

Regulation of the Forkhead Transcription Factor FKHR (FOXO1a) by Glucose Starvation and AICAR, an Activator of AMP-Activated Protein Kinase.

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https://api.crossref.org/works/10.1007%2FS12035-016-0085-Y

21 January 2018

Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

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21 January 2018

The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.

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21 January 2018

Maintenance of C. elegans

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21 January 2018

WormScan: a technique for high-throughput phenotypic analysis of Caenorhabditis elegans

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Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay.

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21 January 2018

Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta

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Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans

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Odorant-selective genes and neurons mediate olfaction in C. elegans.

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Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans.

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21 January 2018

Assaying β-amyloid toxicity using a transgenic C. elegans model

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Sporadic inclusion-body myositis: A degenerative muscle disease associated with aging, impaired muscle protein homeostasis and abnormal mitophagy

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Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans.

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21 January 2018

Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans

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21 January 2018

A semi-automated motion-tracking analysis of locomotion speed in the C. elegans transgenics overexpressing beta-amyloid in neurons

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21 January 2018

Amyloid oligomers: formation and toxicity of Abeta oligomers

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21 January 2018

Molecular action of metformin in hepatocytes: an updated insight

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21 January 2018

Down-regulation of amyloid-β through AMPK activation by inhibitors of GSK-3β in SH-SY5Y and SH-SY5Y-AβPP695 cells

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21 January 2018

AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells.

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21 January 2018

Transgenic C. elegans as a model in Alzheimer's research

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Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity

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Modeling human neurodegenerative diseases in transgenic systems

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Modeling neurodegenerative diseases in Caenorhabditis elegans

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Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes

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Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

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21 January 2018

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

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Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

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Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides

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21 January 2018

Levamisole resistance resolved at the single-channel level in Caenorhabditis elegans.

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The anthelmintic levamisole is an allosteric modulator of human neuronal nicotinic acetylcholine receptors

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Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease.

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Endothelial nicotinic acetylcholine receptors and angiogenesis.

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Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

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Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity

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Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization.

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Cocoa extracts reduce oligomerization of amyloid-β: implications for cognitive improvement in Alzheimer's disease

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Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid

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Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes

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Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.

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5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory mediators in astroglia.

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The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

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Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells

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Aβ peptide secretion is reduced by Radix Polygalae-induced autophagy via activation of the AMPK/mTOR pathway

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Signaling pathway cross talk in Alzheimer's disease

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21 January 2018

Amyloid beta oligomers induce impairment of neuronal insulin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of AMP kinase in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Egg-laying defective mutants of the nematode Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic receptor mutants of the nematode Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genes affecting sensitivity to serotonin in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Diabetes and dementia: the dangerous liaisons? ].

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of metformin on oxidation of NADH-dependent substrates in rat liver homogenate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27596506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12035-016-0085-Y

1 reference

Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

1 reference

Europe PubMed Central

6 April 2018

http://europepmc.org/abstract/MED/27596506

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