Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 (Q33790225)

24889636

29 July 2017

title

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 (English)

1 reference

29 July 2017

1 reference

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1

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6 June 2020

Arne Smolders

4

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6 June 2020

Johan Billen

6

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6 June 2020

Liliane Schoofs

8

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6 June 2020

Liesbet Temmerman

9

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6 June 2020

2

Lotte Frooninckx

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6 June 2020

author name string

Roel Van Assche

3

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6 June 2020

Geert Depuydt

5

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6 June 2020

Bart P Braeckman

7

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6 June 2020

language of work or name

English

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publication date

2 June 2014

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24889636

Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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volume

111

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6 June 2020

issue

24

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6 June 2020

page(s)

E2501-9

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Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

6 June 2020

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Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

4 July 2018

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Interplay between lipids and branched-chain amino acids in development of insulin resistance

4 July 2018

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Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

4 July 2018

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MicroRNA predictors of longevity in Caenorhabditis elegans

4 July 2018

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Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

4 July 2018

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

4 July 2018

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Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways

4 July 2018

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The cell-non-autonomous nature of electron transport chain-mediated longevity

4 July 2018

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Metformin activates AMP kinase through inhibition of AMP deaminase

4 July 2018

1 reference

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Is Overoxidation of Peroxiredoxin Physiologically Significant?

4 July 2018

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Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans

4 July 2018

1 reference

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

4 July 2018

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4 July 2018

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Proteome changes of Caenorhabditis elegans upon a Staphylococcus aureus infection.

4 July 2018

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A metabolic signature of long life in Caenorhabditis elegans

4 July 2018

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Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

4 July 2018

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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

4 July 2018

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Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism

4 July 2018

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Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.

4 July 2018

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Antioxidants prevent health-promoting effects of physical exercise in humans

4 July 2018

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HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line

4 July 2018

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Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

4 July 2018

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4 July 2018

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A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance

4 July 2018

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4 July 2018

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4 July 2018

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

4 July 2018

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4 July 2018

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Two neurons mediate diet-restriction-induced longevity in C. elegans

4 July 2018

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

4 July 2018

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Calorie restriction mimetics: an emerging research field

4 July 2018

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Identification of potential caloric restriction mimetics by microarray profiling

4 July 2018

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The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response

4 July 2018

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Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance

4 July 2018

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Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance

4 July 2018

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Aging: a theory based on free radical and radiation chemistry

4 July 2018

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Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid

4 July 2018

1 reference

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A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity

4 July 2018

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Assaying metabolic activity in ageing Caenorhabditis elegans

4 July 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

4 July 2018

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Essential roles for four cytoplasmic intermediate filament proteins in Caenorhabditis elegans development

4 July 2018

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

4 July 2018

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

4 July 2018

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Metformin slows down aging and extends life span of female SHR mice.

4 July 2018

1 reference

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PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

21 January 2018

1 reference

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Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration.

21 January 2018

1 reference

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Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin.

21 January 2018

1 reference

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Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes

21 January 2018

1 reference

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Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

1 reference

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Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals.

21 January 2018

1 reference

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Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

30 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1321776111

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24889636

inferred from PubMed ID database lookup

12 December 2020

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Beneficial effects of l-leucine and l-valine on arrhythmias, hemodynamics and myocardial morphology in rats

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24889636

inferred from PubMed ID database lookup

12 December 2020

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Identifiers

DOI

10.1073/PNAS.1321776111

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6 June 2020

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6 June 2020

24889636

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